Correction for Dooley et al,. First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate

Immunology. For the article “First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate,” by Helen Dooley, Robyn L. Stanfield, Rebecca A. Brady, and Martin F. Flajnik, which appeared in issue 6, February 7, 2006, of Proc. Natl. Acad. Sci. USA (103, 1846–1851; first published January 30, 2006; 10.1073/pnas.0508341103), the authors note that on page 1849, the last sentence of the first paragraph, left column, “The 10-fold increase in affinity observed for PBLA8 when compared with ancestral is mainly a consequence of a slower dissociation rate (≈5-fold slower than ancestral), whereas association rate is only fractionally improved (≈2-fold),” should read: “The 10-fold increase in affinity observed for PBLA8 when compared with ancestral is a consequence of its much slower dissociation rate (≈20-fold slower than ancestral), whereas its association rate is actually fractionally slower (≈2-fold).” This error does not affect the conclusions of the article.