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. Author manuscript; available in PMC: 2006 Oct 12.
Published in final edited form as: JAMA. 2006 Apr 12;295(14):1658–1667. doi: 10.1001/jama.295.14.1658

Figure 1. Treatment Regimens in the Three Studies of Chemotherapy for Node-Positive Breast Cancer.

Figure 1

C denotes cyclophosphamide, A doxorubicin, F fluorouracil, and P paclitaxel. Study 8541 had three treatment arms, with doses of C, A and F in proportion to the dose of doxorubicin that is shown (in milligrams per square meter of body surface area). Study 9344 had a 3 by 2 factorial design, with randomization to one of 3 doses of A with a second randomization to 4 cycles of paclitaxel or not. Study 9741 had a 2 by 2 factorial design, with patients being randomized to biweekly vs triweekly schedules and separately to concurrent AC followed by P vs sequential A followed by P then C.