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. 1998 Nov;150(3):1239–1244. doi: 10.1093/genetics/150.3.1239

Positive correlation between recombination rates and levels of genetic variation in natural populations of sea beet (Beta vulgaris subsp. maritima).

T Kraft 1, T Säll 1, I Magnusson-Rading 1, N O Nilsson 1, C Halldén 1
PMCID: PMC1460383  PMID: 9799275

Abstract

The relation between the level of genetic variation and the rate of recombination per physical unit was investigated in sea beet (Beta vulgaris subsp. maritima). The rate of recombination per physical unit was estimated indirectly through marker density in an RFLP linkage map of sugar beet. From this map, we also selected RFLP markers covering two of the nine chromosomes in Beta. The markers were used to estimate the level of genetic variation in three populations of sea beet, two from Italy and one from England. Two estimates of genetic variation were employed, one based on the number of alleles in the sample and the other on heterozygosity. A statistically significant positive correlation was found between recombination rate and genetic variation. Several theoretical explanations for this are discussed, background selection being one. A correlation similar to this has been observed previously in Drosophila, one that was higher than what we obtained for Beta. This is consistent with various biological differences between the two species.

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Selected References

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  1. Adam-Blondon A. F., Sevignac M., Dron M., Bannerot H. A genetic map of common bean to localize specific resistance genes against anthracnose. Genome. 1994 Dec;37(6):915–924. doi: 10.1139/g94-131. [DOI] [PubMed] [Google Scholar]
  2. Aguade M., Miyashita N., Langley C. H. Reduced variation in the yellow-achaete-scute region in natural populations of Drosophila melanogaster. Genetics. 1989 Jul;122(3):607–615. doi: 10.1093/genetics/122.3.607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Begun D. J., Aquadro C. F. Levels of naturally occurring DNA polymorphism correlate with recombination rates in D. melanogaster. Nature. 1992 Apr 9;356(6369):519–520. doi: 10.1038/356519a0. [DOI] [PubMed] [Google Scholar]
  4. Bennett M. D., Smith J. B. Nuclear dna amounts in angiosperms. Philos Trans R Soc Lond B Biol Sci. 1976 May 27;274(933):227–274. doi: 10.1098/rstb.1976.0044. [DOI] [PubMed] [Google Scholar]
  5. Bevan M., Bancroft I., Bent E., Love K., Goodman H., Dean C., Bergkamp R., Dirkse W., Van Staveren M., Stiekema W. Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana. Nature. 1998 Jan 29;391(6666):485–488. doi: 10.1038/35140. [DOI] [PubMed] [Google Scholar]
  6. Bird A. P. Gene number, noise reduction and biological complexity. Trends Genet. 1995 Mar;11(3):94–100. doi: 10.1016/S0168-9525(00)89009-5. [DOI] [PubMed] [Google Scholar]
  7. Braverman J. M., Hudson R. R., Kaplan N. L., Langley C. H., Stephan W. The hitchhiking effect on the site frequency spectrum of DNA polymorphisms. Genetics. 1995 Jun;140(2):783–796. doi: 10.1093/genetics/140.2.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Causse M. A., Fulton T. M., Cho Y. G., Ahn S. N., Chunwongse J., Wu K., Xiao J., Yu Z., Ronald P. C., Harrington S. E. Saturated molecular map of the rice genome based on an interspecific backcross population. Genetics. 1994 Dec;138(4):1251–1274. doi: 10.1093/genetics/138.4.1251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Charlesworth B. Background selection and patterns of genetic diversity in Drosophila melanogaster. Genet Res. 1996 Oct;68(2):131–149. doi: 10.1017/s0016672300034029. [DOI] [PubMed] [Google Scholar]
  10. Charlesworth B., Morgan M. T., Charlesworth D. The effect of deleterious mutations on neutral molecular variation. Genetics. 1993 Aug;134(4):1289–1303. doi: 10.1093/genetics/134.4.1289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Charlesworth D., Charlesworth B., Morgan M. T. The pattern of neutral molecular variation under the background selection model. Genetics. 1995 Dec;141(4):1619–1632. doi: 10.1093/genetics/141.4.1619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Donnelly P., Tavaré S. Coalescents and genealogical structure under neutrality. Annu Rev Genet. 1995;29:401–421. doi: 10.1146/annurev.ge.29.120195.002153. [DOI] [PubMed] [Google Scholar]
  13. Dvorák J., Luo M. C., Yang Z. L. Restriction fragment length polymorphism and divergence in the genomic regions of high and low recombination in self-fertilizing and cross-fertilizing aegilops species. Genetics. 1998 Jan;148(1):423–434. doi: 10.1093/genetics/148.1.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ewens W. J. The sampling theory of selectively neutral alleles. Theor Popul Biol. 1972 Mar;3(1):87–112. doi: 10.1016/0040-5809(72)90035-4. [DOI] [PubMed] [Google Scholar]
  15. Halldén C., Hjerdin A., Rading I. M., Fridlundh B., Johannisdottir G., Tuvesson S., Akesson C., Säll T., Nilsson N. O. A high density RFLP linkage map of sugar beet. Genome. 1996 Aug;39(4):634–645. doi: 10.1139/g96-081. [DOI] [PubMed] [Google Scholar]
  16. Hudson R. R. How can the low levels of DNA sequence variation in regions of the drosophila genome with low recombination rates be explained? Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6815–6818. doi: 10.1073/pnas.91.15.6815. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Kaplan N. L., Hudson R. R., Langley C. H. The "hitchhiking effect" revisited. Genetics. 1989 Dec;123(4):887–899. doi: 10.1093/genetics/123.4.887. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kraft T., Säll T., Fridlund B., Hjerdin A., Tuvesson S., Halldén C. Estimating genetic variation in sugar beets and wild beets using pools of individuals. Genome. 1997 Aug;40(4):527–533. doi: 10.1139/g97-069. [DOI] [PubMed] [Google Scholar]
  19. Nachman M. W., Churchill G. A. Heterogeneity in rates of recombination across the mouse genome. Genetics. 1996 Feb;142(2):537–548. doi: 10.1093/genetics/142.2.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Nachman M. W. Patterns of DNA variability at X-linked loci in Mus domesticus. Genetics. 1997 Nov;147(3):1303–1316. doi: 10.1093/genetics/147.3.1303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Nordborg M., Charlesworth B., Charlesworth D. The effect of recombination on background selection. Genet Res. 1996 Apr;67(2):159–174. doi: 10.1017/s0016672300033619. [DOI] [PubMed] [Google Scholar]
  22. Stephan W., Langley C. H. Molecular genetic variation in the centromeric region of the X chromosome in three Drosophila ananassae populations. I. Contrasts between the vermilion and forked loci. Genetics. 1989 Jan;121(1):89–99. doi: 10.1093/genetics/121.1.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Tanksley S. D., Ganal M. W., Prince J. P., de Vicente M. C., Bonierbale M. W., Broun P., Fulton T. M., Giovannoni J. J., Grandillo S., Martin G. B. High density molecular linkage maps of the tomato and potato genomes. Genetics. 1992 Dec;132(4):1141–1160. doi: 10.1093/genetics/132.4.1141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Wiehe T. H., Stephan W. Analysis of a genetic hitchhiking model, and its application to DNA polymorphism data from Drosophila melanogaster. Mol Biol Evol. 1993 Jul;10(4):842–854. doi: 10.1093/oxfordjournals.molbev.a040046. [DOI] [PubMed] [Google Scholar]

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