Skip to main content
NCBI home page
Genetics logoLink to Genetics
. 1998 Nov;150(3):1125–1131. doi: 10.1093/genetics/150.3.1125

Mouse Brachyury the Second (T2) is a gene next to classical T and a candidate gene for tct.

G Rennebeck 1, E Lader 1, A Fujimoto 1, E P Lei 1, K Artzt 1
PMCID: PMC1460395  PMID: 9799264

Abstract

The mouse Brachyury the Second (T2) gene is 15 kb away from classical Brachyury (T). A mutation in T2 disrupts notochord development, pointing to the existence of a second T/t complex gene involved in axis development. T2 encodes a novel protein that is disrupted by an insertion in T2(Bob) mice. Sequence analysis of T2 from several t haplotypes shows that they all share the same changed stop codon, and, thus, T2 is a candidate gene for the t complex tail interaction factor. T1, T2, and the unlinked t-int are distinct and unrelated loci, and mutations in these genes do not complement one another genetically. Either their products interact in the same pathway during the genesis of the embryonic axis, or the T/t region itself is truly complex.

Full Text

The Full Text of this article is available as a PDF (168.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Conlon F. L., Wright C. V., Robertson E. J. Effects of the TWis mutation on notochord formation and mesodermal patterning. Mech Dev. 1995 Feb;49(3):201–209. doi: 10.1016/0925-4773(94)00318-h. [DOI] [PubMed] [Google Scholar]
  2. Copp A. J. Death before birth: clues from gene knockouts and mutations. Trends Genet. 1995 Mar;11(3):87–93. doi: 10.1016/S0168-9525(00)89008-3. [DOI] [PubMed] [Google Scholar]
  3. Estibeiro J. P., Brook F. A., Copp A. J. Interaction between splotch (Sp) and curly tail (ct) mouse mutants in the embryonic development of neural tube defects. Development. 1993 Sep;119(1):113–121. doi: 10.1242/dev.119.1.113. [DOI] [PubMed] [Google Scholar]
  4. Helwig U., Imai K., Schmahl W., Thomas B. E., Varnum D. S., Nadeau J. H., Balling R. Interaction between undulated and Patch leads to an extreme form of spina bifida in double-mutant mice. Nat Genet. 1995 Sep;11(1):60–63. doi: 10.1038/ng0995-60. [DOI] [PubMed] [Google Scholar]
  5. Herrmann B. G. Expression pattern of the Brachyury gene in whole-mount TWis/TWis mutant embryos. Development. 1991 Nov;113(3):913–917. doi: 10.1242/dev.113.3.913. [DOI] [PubMed] [Google Scholar]
  6. Herrmann B. G., Labeit S., Poustka A., King T. R., Lehrach H. Cloning of the T gene required in mesoderm formation in the mouse. Nature. 1990 Feb 15;343(6259):617–622. doi: 10.1038/343617a0. [DOI] [PubMed] [Google Scholar]
  7. Kispert A., Herrmann B. G. The Brachyury gene encodes a novel DNA binding protein. EMBO J. 1993 Aug;12(8):3211–3220. doi: 10.1002/j.1460-2075.1993.tb05990.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MacMurray A., Shin H. S. The antimorphic nature of the Tc allele at the mouse T locus. Genetics. 1988 Oct;120(2):545–550. doi: 10.1093/genetics/120.2.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Nadeau J. H., Varnum D., Burkart D. Genetic evidence for two t complex tail interaction (tct) loci in t haplotypes. Genetics. 1989 Aug;122(4):895–903. doi: 10.1093/genetics/122.4.895. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Oettinger M. A., Schatz D. G., Gorka C., Baltimore D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science. 1990 Jun 22;248(4962):1517–1523. doi: 10.1126/science.2360047. [DOI] [PubMed] [Google Scholar]
  11. Park C. H., Pruitt J. H., Bennett D. A mouse model for neural tube defects: the curtailed (Tc) mutation produces spina bifida occulta in Tc/+ animals and spina bifida with meningomyelocele in Tc/t. Teratology. 1989 Mar;39(3):303–312. doi: 10.1002/tera.1420390312. [DOI] [PubMed] [Google Scholar]
  12. Rennebeck G. M., Lader E., Chen Q., Bohm R. A., Cai Z. S., Faust C., Magnuson T., Pease L. R., Artzt K. Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Dev Biol. 1995 Nov;172(1):206–217. doi: 10.1006/dbio.1995.0016. [DOI] [PubMed] [Google Scholar]
  13. Searle A. G. Curtailed, a new dominant T-allele in the house mouse. Genet Res. 1966 Feb;7(1):86–95. doi: 10.1017/s0016672300009496. [DOI] [PubMed] [Google Scholar]
  14. Silver L. M., Hammer M., Fox H., Garrels J., Bucan M., Herrmann B., Frischauf A. M., Lehrach H., Winking H., Figueroa F. Molecular evidence for the rapid propagation of mouse t haplotypes from a single, recent, ancestral chromosome. Mol Biol Evol. 1987 Sep;4(5):473–482. doi: 10.1093/oxfordjournals.molbev.a040457. [DOI] [PubMed] [Google Scholar]
  15. Stott D., Kispert A., Herrmann B. G. Rescue of the tail defect of Brachyury mice. Genes Dev. 1993 Feb;7(2):197–203. doi: 10.1101/gad.7.2.197. [DOI] [PubMed] [Google Scholar]
  16. Zanelli E., Zhou P., Cao H., Smart M. K., David C. S. Genomic organization and tissue expression of the mouse proteasome gene Lmp-7. Immunogenetics. 1993;38(6):400–407. doi: 10.1007/BF00184520. [DOI] [PubMed] [Google Scholar]
  17. Zhou X., Glas R., Momburg F., Hämmerling G. J., Jondal M., Ljunggren H. G. TAP2-defective RMA-S cells present Sendai virus antigen to cytotoxic T lymphocytes. Eur J Immunol. 1993 Aug;23(8):1796–1801. doi: 10.1002/eji.1830230810. [DOI] [PubMed] [Google Scholar]

Articles from Genetics are provided here courtesy of Oxford University Press

RESOURCES