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. 1998 Nov;150(3):1155–1168. doi: 10.1093/genetics/150.3.1155

Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11.

P Liu 1, H Zhang 1, A McLellan 1, H Vogel 1, A Bradley 1
PMCID: PMC1460401  PMID: 9799267

Abstract

Chromosome engineering in mice enables the construction of models of human chromosomal diseases and provides key reagents for genetic studies. To begin to define functional information for a small portion of chromosome 11, deficiencies, duplications, and inversions were constructed in embryonic stem cells with sizes ranging from 1 Mb to 22 cM. Two deficiencies and three duplications were established in the mouse germline. Mice with a 1-Mb duplication developed corneal hyperplasia and thymic tumors, while two different 3- to 4-cM deficiencies were embryonically lethal in heterozygous mice. A duplication corresponding to one of these two deficiencies was able to rescue its haplolethality.

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Selected References

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