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. 1998 Dec;150(4):1577–1584. doi: 10.1093/genetics/150.4.1577

Isochore evolution in mammals: a human-like ancestral structure.

N Galtier 1, D Mouchiroud 1
PMCID: PMC1460440  PMID: 9832533

Abstract

Codon usage in mammals is mainly determined by the spatial arrangement of genomic G + C-content, i.e., the isochore structure. Ancestral G + C-content at third codon positions of 27 nuclear protein-coding genes of eutherian mammals was estimated by maximum-likelihood analysis on the basis of a nonhomogeneous DNA substitution model, accounting for variable base compositions among present-day sequences. Data consistently supported a human-like ancestral pattern, i.e., highly variable G + C-content among genes. The mouse genomic structure-more narrow G + C-content distribution-would be a derived state. The circumstances of isochore evolution are discussed with respect to this result. A possible relationship between G + C-content homogenization in murid genomes and high mutation rate is proposed, consistent with the negative selection hypothesis for isochore maintenance in mammals.

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Selected References

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