. 2006 May;173(1):111–130. doi: 10.1534/genetics.105.054007

TABLE 2.

C. elegans adenylyl cyclases

C. elegans protein name	Closest human homolog	BLASTP smallest sum probablility relative to ACY-1	BLASTP smallest sum probability relative to closest human homolog and (% identity)
ACY-1	Adenylyl cyclase, type IX	—	3.3e-166 (32)
ACY-4	Adenylyl cyclase, type VI Ca(2+)-inhibitable adenylyl cyclase	6.6e-60	3.0e-163 (32)
ACY-2	Adenylyl cyclase, type II (=mouse type IV)	6.0e-37	8.2e-131 (28)
ACY-3 (ortholog of fly Rutabaga)	Adenylyl cyclase, type VIII Ca²⁺/calmodulin activated adenylyl cyclase	0.058	4.4e-44 (9)

Column 1 lists all C. elegans proteins producing “high-scoring segment pairs” in a TBLASTN 2.0MP search of the C. elegans genome using ACY-1 as the query. Closely related guanylyl cyclases, of which there are many in C. elegans, are not included. The proteins are listed in order of their similarity to ACY-1 on the basis of BLASTP smallest sum probabilities. Closest human homolog descriptions and the corresponding smallest sum probabilities are taken from WormBase Release WS148 (http://www.wormbase.org). Percentage identities were calculated using Vector NTI AlignX and do not include nonaligning N- or C- terminal ends of each protein pair. Accession numbers for the C. elegans/human proteins are: ACY-1 (NP_497970/ O60503); ACY-2 (NP_504553/ Q08462); ACY-3 (NP_497765/ P40145); ACY-4 (NP_504486/ O43306).