TABLE 1.

soc-1/Gab1 suppresses the multi-vulva phenotype arising from a gain-of-function Ras mutation

Genotype	Average inductiona	% Muvb	n
+/+	3.0	0	Many
let-60(n1046gf)	3.9	80	45
let-60(n1046gf); sem-5(n2195)G201R	3.2	18	40
let-60(n1046gf); soc-1(n1789)	3.5	53	36
ptp-2(op194); let-60(n1046gf)	3.4	56	41

soc-1(n1789) and ptp-2(op194) are null mutations. ptp-2 was linked to unc-4(e120). Suppression of let-60(gf) by sem-5(n2195), soc-1(0), and ptp-2(0) was significant (Fisher's exact test P < 0.05). A significantly greater number of animals with more than three cells was induced in let-60ras(gf); soc-1(0) and ptp-2(0); let-60ras(gf) relative to let-60ras(gf); sem-5(n2195) animals (Fisher's exact test P < 0.05). There was no difference between let-60ras(gf); soc-1(0) and ptp-2(0); let-60ras(gf) (Fisher's exact test P = 0.82).

^aTotal number of VPCs adopting a vulval cell fate divided by the number of animals scored.

^bProportion of animals having more than three VPCs induced.