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. 1996 Oct 1;24(19):3873–3874. doi: 10.1093/nar/24.19.3873

Gene transfer mediated by alpha2-macroglobulin.

H Schneider 1, K Huse 1, G Birkenmeier 1, A Otto 1, G H Scholz 1
PMCID: PMC146155  PMID: 8871570

Abstract

alpha2-Macroglobulin covalently linked to poly(L)-lysine can be used as a vehicle for receptor-mediated gene transfer. This modified alpha2-macroglobulin maintains its ability to bind to the alpha2-macroglobulin receptor, and was shown to introduce a luciferase reporter gene plasmid into HepG2 human hepatoma cells in vitro. The alpha2-macroglobulin receptor is a very large and multifunctional cell surface receptor, whose rapid and efficient internalization rate makes it attractive for gene therapy, e.g. for hepatic gene targeting via injection into the portal vein.

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Selected References

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