Abstract
Negative interference describes a situation where two genetic regions have more double crossovers than would be expected considering the crossover rate of each region. We detected negative crossover interference while attempting to genetically map translocation breakpoints in maize. In an attempt to find precedent examples we determined there was negative interference among previously published translocation breakpoint mapping data in maize. It appears that negative interference was greater when the combined map length of the adjacent regions was smaller. Even positive interference appears to have been reduced when the combined lengths of adjacent regions were below 40 cM. Both phenomena can be explained by a reduction in crossovers near the breakpoints or, more specifically, by a failure of regions near breakpoints to become competent for crossovers. A mathematical explanation is provided.
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Selected References
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- Anderson E G, Brink R A. Translocations in Maize Involving Chromosome 3. Genetics. 1940 May;25(3):299–309. doi: 10.1093/genetics/25.3.299. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Anderson E G, Kramer H H, Longley A E. Translocations in Maize Involving Chromosome 4. Genetics. 1955 Jul;40(4):500–510. doi: 10.1093/genetics/40.4.500. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Anderson E G. Translocations in Maize Involving Chromosome 9. Genetics. 1938 May;23(3):307–313. doi: 10.1093/genetics/23.3.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Anderson E G. Translocations in Maize Involving the Short Arm of Chromosome I. Genetics. 1941 Jul;26(4):452–459. doi: 10.1093/genetics/26.4.452. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lindegren C. C. Non-Mendelian Segregation in a Single Tetrad of Saccharomyces Ascribed to Gene Conversion. Science. 1955 Apr 22;121(3147):605–607. doi: 10.1126/science.121.3147.605. [DOI] [PubMed] [Google Scholar]
- McClintock B, Hill H E. The Cytological Identification of the Chromosome Associated with the R-G Linkage Group in ZEA MAYS. Genetics. 1931 Mar;16(2):175–190. doi: 10.1093/genetics/16.2.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Muller H J, Jacobs-Muller J M. The Standard Errors of Chromosome Distances and Coincidence. Genetics. 1925 Nov;10(6):509–524. doi: 10.1093/genetics/10.6.509. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rappold G. A., Klink A., Weiss B., Fischer C. Double crossover in the human Xp/Yp pseudoautosomal region and its bearing on interference. Hum Mol Genet. 1994 Aug;3(8):1337–1340. doi: 10.1093/hmg/3.8.1337. [DOI] [PubMed] [Google Scholar]
- Rhoades M. M. A Secondary Trisome in Maize. Proc Natl Acad Sci U S A. 1933 Dec;19(12):1031–1038. doi: 10.1073/pnas.19.12.1031. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Salamini F., Lorenzoni C. Genetical analysis of glossy mutants of maize. 3. Intracistron recombination and high negative interference at the gl-1 locus. Mol Gen Genet. 1970;108(3):225–232. doi: 10.1007/BF00283352. [DOI] [PubMed] [Google Scholar]
- Sinclair D. A. Crossing over between closely linked markers spanning the centromere of chromosome 3 in drosophila melanogaster. Genet Res. 1975 Oct;26(2):173–185. doi: 10.1017/s0016672300015974. [DOI] [PubMed] [Google Scholar]
- Sprague G F. The Nature and Extent of Hetero-Fertilization in Maize. Genetics. 1932 May;17(3):358–368. doi: 10.1093/genetics/17.3.358. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sym M., Roeder G. S. Crossover interference is abolished in the absence of a synaptonemal complex protein. Cell. 1994 Oct 21;79(2):283–292. doi: 10.1016/0092-8674(94)90197-x. [DOI] [PubMed] [Google Scholar]
- Säll T., Bengtsson B. O. Apparent negative interference due to variation in recombination frequencies. Genetics. 1989 Aug;122(4):935–942. doi: 10.1093/genetics/122.4.935. [DOI] [PMC free article] [PubMed] [Google Scholar]