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. 2002 Jan;160(1):353–355. doi: 10.1093/genetics/160.1.353

A simple formula useful for positional cloning.

Richard T Durrett 1, Kai-Yi Chen 1, Steven D Tanksley 1
PMCID: PMC1461938  PMID: 11805070

Abstract

We derive a formula for the distribution of the length T of the recombination interval containing a target gene and using N gametes in a region where R kilobases correspond to 1 cM. The formula can be used to calculate the number of meiotic events required to narrow a target gene down to a specific interval size and hence should be useful for planning positional cloning experiments. The predictions of this formula agree well with the results from a number of published experiments in Arabidopsis.

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Selected References

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