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. 2002 Feb;160(2):799–803. doi: 10.1093/genetics/160.2.799

Caenorhabditis elegans unc-37/groucho interacts genetically with components of the transcriptional mediator complex.

Hong Zhang 1, Scott W Emmons 1
PMCID: PMC1461970  PMID: 11861580

Abstract

Groucho functions as a general corepressor by modulating chromatin structure and has a widespread role in many developmental processes. Here we show that Groucho may also interact with the basal transcriptional machinery. Mutations in Caenorhabditis elegans groucho interact with mutations in components of the transcriptional Mediator complex, resulting in synthetic lethality and loss of male sensory neurons.

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Selected References

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  1. Barr M. M., Sternberg P. W. A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. Nature. 1999 Sep 23;401(6751):386–389. doi: 10.1038/43913. [DOI] [PubMed] [Google Scholar]
  2. Björklund S., Almouzni G., Davidson I., Nightingale K. P., Weiss K. Global transcription regulators of eukaryotes. Cell. 1999 Mar 19;96(6):759–767. doi: 10.1016/s0092-8674(00)80586-3. [DOI] [PubMed] [Google Scholar]
  3. Boyer T. G., Martin M. E., Lees E., Ricciardi R. P., Berk A. J. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein. Nature. 1999 May 20;399(6733):276–279. doi: 10.1038/20466. [DOI] [PubMed] [Google Scholar]
  4. Carlson M. Genetics of transcriptional regulation in yeast: connections to the RNA polymerase II CTD. Annu Rev Cell Dev Biol. 1997;13:1–23. doi: 10.1146/annurev.cellbio.13.1.1. [DOI] [PubMed] [Google Scholar]
  5. Cavallo R. A., Cox R. T., Moline M. M., Roose J., Polevoy G. A., Clevers H., Peifer M., Bejsovec A. Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature. 1998 Oct 8;395(6702):604–608. doi: 10.1038/26982. [DOI] [PubMed] [Google Scholar]
  6. Chen G., Courey A. J. Groucho/TLE family proteins and transcriptional repression. Gene. 2000 May 16;249(1-2):1–16. doi: 10.1016/s0378-1119(00)00161-x. [DOI] [PubMed] [Google Scholar]
  7. Chen G., Fernandez J., Mische S., Courey A. J. A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development. Genes Dev. 1999 Sep 1;13(17):2218–2230. doi: 10.1101/gad.13.17.2218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Edmondson D. G., Smith M. M., Roth S. Y. Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4. Genes Dev. 1996 May 15;10(10):1247–1259. doi: 10.1101/gad.10.10.1247. [DOI] [PubMed] [Google Scholar]
  9. Eisenmann D. M., Maloof J. N., Simske J. S., Kenyon C., Kim S. K. The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development. Development. 1998 Sep;125(18):3667–3680. doi: 10.1242/dev.125.18.3667. [DOI] [PubMed] [Google Scholar]
  10. Horvitz H. R., Sternberg P. W., Greenwald I. S., Fixsen W., Ellis H. M. Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol. 1983;48(Pt 2):453–463. doi: 10.1101/sqb.1983.048.01.050. [DOI] [PubMed] [Google Scholar]
  11. Hunter C. P., Harris J. M., Maloof J. N., Kenyon C. Hox gene expression in a single Caenorhabditis elegans cell is regulated by a caudal homolog and intercellular signals that inhibit wnt signaling. Development. 1999 Feb;126(4):805–814. doi: 10.1242/dev.126.4.805. [DOI] [PubMed] [Google Scholar]
  12. Korswagen H. C., Herman M. A., Clevers H. C. Distinct beta-catenins mediate adhesion and signalling functions in C. elegans. Nature. 2000 Aug 3;406(6795):527–532. doi: 10.1038/35020099. [DOI] [PubMed] [Google Scholar]
  13. Levanon D., Goldstein R. E., Bernstein Y., Tang H., Goldenberg D., Stifani S., Paroush Z., Groner Y. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11590–11595. doi: 10.1073/pnas.95.20.11590. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mannervik M., Nibu Y., Zhang H., Levine M. Transcriptional coregulators in development. Science. 1999 Apr 23;284(5414):606–609. doi: 10.1126/science.284.5414.606. [DOI] [PubMed] [Google Scholar]
  15. Pflugrad A., Meir J. Y., Barnes T. M., Miller D. M., 3rd The Groucho-like transcription factor UNC-37 functions with the neural specificity gene unc-4 to govern motor neuron identity in C. elegans. Development. 1997 May;124(9):1699–1709. doi: 10.1242/dev.124.9.1699. [DOI] [PubMed] [Google Scholar]
  16. Polakis P. Wnt signaling and cancer. Genes Dev. 2000 Aug 1;14(15):1837–1851. [PubMed] [Google Scholar]
  17. Roose J., Molenaar M., Peterson J., Hurenkamp J., Brantjes H., Moerer P., van de Wetering M., Destrée O., Clevers H. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature. 1998 Oct 8;395(6702):608–612. doi: 10.1038/26989. [DOI] [PubMed] [Google Scholar]
  18. Singh N., Han M. sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction. Genes Dev. 1995 Sep 15;9(18):2251–2265. doi: 10.1101/gad.9.18.2251. [DOI] [PubMed] [Google Scholar]
  19. Wahi M., Komachi K., Johnson A. D. Gene regulation by the yeast Ssn6-Tup1 corepressor. Cold Spring Harb Symp Quant Biol. 1998;63:447–457. doi: 10.1101/sqb.1998.63.447. [DOI] [PubMed] [Google Scholar]
  20. Waring D. A., Kenyon C. Selective silencing of cell communication influences anteroposterior pattern formation in C. elegans. Cell. 1990 Jan 12;60(1):123–131. doi: 10.1016/0092-8674(90)90722-q. [DOI] [PubMed] [Google Scholar]
  21. Watson A. D., Edmondson D. G., Bone J. R., Mukai Y., Yu Y., Du W., Stillman D. J., Roth S. Y. Ssn6-Tup1 interacts with class I histone deacetylases required for repression. Genes Dev. 2000 Nov 1;14(21):2737–2744. doi: 10.1101/gad.829100. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Winnier A. R., Meir J. Y., Ross J. M., Tavernarakis N., Driscoll M., Ishihara T., Katsura I., Miller D. M., 3rd UNC-4/UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans. Genes Dev. 1999 Nov 1;13(21):2774–2786. doi: 10.1101/gad.13.21.2774. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Wrischnik L. A., Kenyon C. J. The role of lin-22, a hairy/enhancer of split homolog, in patterning the peripheral nervous system of C. elegans. Development. 1997 Aug;124(15):2875–2888. doi: 10.1242/dev.124.15.2875. [DOI] [PubMed] [Google Scholar]
  24. Zhang H., Emmons S. W. A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene. Genes Dev. 2000 Sep 1;14(17):2161–2172. doi: 10.1101/gad.814700. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Zhang H., Emmons S. W. The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox gene expression. Development. 2001 Mar;128(5):767–777. doi: 10.1242/dev.128.5.767. [DOI] [PubMed] [Google Scholar]

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