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. 2002 Feb;160(2):793–798. doi: 10.1093/genetics/160.2.793

Comparative analysis of the human dystrophin and utrophin gene structures.

Uberto Pozzoli 1, Manuela Sironi 1, Rachele Cagliani 1, Giacomo P Comi 1, Alessandra Bardoni 1, Nereo Bresolin 1
PMCID: PMC1461978  PMID: 11861579

Abstract

We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.

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Selected References

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