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. 2002 Aug;161(4):1625–1632. doi: 10.1093/genetics/161.4.1625

Exploring alternative models for sex-linked quantitative trait loci in outbred populations: application to an iberian x landrace pig intercross.

Miguel Pérez-Enciso 1, Alex Clop 1, Josep M Folch 1, Armand Sánchez 1, Maria A Oliver 1, Cristina Ovilo 1, C Barragán 1, Luis Varona 1, José L Noguera 1
PMCID: PMC1462213  PMID: 12196405

Abstract

We present a very flexible method that allows us to analyze X-linked quantitative trait loci (QTL) in crosses between outbred lines. The dosage compensation phenomenon is modeled explicitly in an identity-by-descent approach. A variety of models can be fitted, ranging from considering alternative fixed alleles within the founder breeds to a model where the only genetic variation is within breeds, as well as mixed models. Different genetic variances within each founder breed can be estimated. We illustrate the method with data from an F(2) cross between Iberian x Landrace pigs for intramuscular fat content and meat color component a*. The Iberian allele exhibited a strong overdominant effect for intramuscular fat in females. There was also limited evidence of one or more regions affecting color component a*. The analysis suggested that the QTL alleles were fixed in the Iberian founders, whereas there was some evidence of segregation in Landrace for the QTL affecting a* color component.

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Selected References

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