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. 2002 Aug;161(4):1651–1659. doi: 10.1093/genetics/161.4.1651

X chromosome effect on maternal recombination and meiotic drive in the mouse.

Elena de La Casa-Esperón 1, J Concepción Loredo-Osti 1, Fernando Pardo-Manuel de Villena 1, Tammi L Briscoe 1, Jan Michel Malette 1, Joe E Vaughan 1, Kenneth Morgan 1, Carmen Sapienza 1
PMCID: PMC1462220  PMID: 12196408

Abstract

We observed that maternal meiotic drive favoring the inheritance of DDK alleles at the Om locus on mouse chromosome 11 was correlated with the X chromosome inactivation phenotype of (C57BL/6-Pgk1(a) x DDK)F(1) mothers. The basis for this unexpected observation appears to lie in the well-documented effect of recombination on meiotic drive that results from nonrandom segregation of chromosomes. Our analysis of genome-wide levels of meiotic recombination in females that vary in their X-inactivation phenotype indicates that an allelic difference at an X-linked locus is responsible for modulating levels of recombination in oocytes.

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Selected References

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