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. 2003 Jun;164(2):821–828. doi: 10.1093/genetics/164.2.821

An argonaute-like protein is required for meiotic silencing.

Dong W Lee 1, Robert J Pratt 1, Malcolm McLaughlin 1, Rodolfo Aramayo 1
PMCID: PMC1462569  PMID: 12807800

Abstract

We demonstrate the involvement of suppressor of meiotic silencing-2 (sms-2(+)), a Neurospora gene coding for an Argonaute-like protein, in meiotic silencing and normal sexual development.

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Selected References

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  1. Allshire Robin. Molecular biology. RNAi and heterochromatin--a hushed-up affair. Science. 2002 Aug 22;297(5588):1818–1819. doi: 10.1126/science.1075874. [DOI] [PubMed] [Google Scholar]
  2. Ambros V. microRNAs: tiny regulators with great potential. Cell. 2001 Dec 28;107(7):823–826. doi: 10.1016/s0092-8674(01)00616-x. [DOI] [PubMed] [Google Scholar]
  3. Aramayo R., Metzenberg R. L. Meiotic transvection in fungi. Cell. 1996 Jul 12;86(1):103–113. doi: 10.1016/s0092-8674(00)80081-1. [DOI] [PubMed] [Google Scholar]
  4. Bernard P., Maure J. F., Partridge J. F., Genier S., Javerzat J. P., Allshire R. C. Requirement of heterochromatin for cohesion at centromeres. Science. 2001 Oct 11;294(5551):2539–2542. doi: 10.1126/science.1064027. [DOI] [PubMed] [Google Scholar]
  5. Carmell Michelle A., Xuan Zhenyu, Zhang Michael Q., Hannon Gregory J. The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev. 2002 Nov 1;16(21):2733–2742. doi: 10.1101/gad.1026102. [DOI] [PubMed] [Google Scholar]
  6. Catalanotto C., Azzalin G., Macino G., Cogoni C. Gene silencing in worms and fungi. Nature. 2000 Mar 16;404(6775):245–245. doi: 10.1038/35005169. [DOI] [PubMed] [Google Scholar]
  7. Catalanotto Caterina, Azzalin Gianluca, Macino Giuseppe, Cogoni Carlo. Involvement of small RNAs and role of the qde genes in the gene silencing pathway in Neurospora. Genes Dev. 2002 Apr 1;16(7):790–795. doi: 10.1101/gad.222402. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cogoni C., Macino G. Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10233–10238. doi: 10.1073/pnas.94.19.10233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Dernburg Abby F., Karpen Gary H. A chromosome RNAissance. Cell. 2002 Oct 18;111(2):159–162. doi: 10.1016/s0092-8674(02)01039-5. [DOI] [PubMed] [Google Scholar]
  10. Galagan James E., Calvo Sarah E., Borkovich Katherine A., Selker Eric U., Read Nick D., Jaffe David, FitzHugh William, Ma Li-Jun, Smirnov Serge, Purcell Seth. The genome sequence of the filamentous fungus Neurospora crassa. Nature. 2003 Apr 24;422(6934):859–868. doi: 10.1038/nature01554. [DOI] [PubMed] [Google Scholar]
  11. Griffiths A. J., Delange A. M. Mutations of the a Mating-Type Gene in NEUROSPORA CRASSA. Genetics. 1978 Feb;88(2):239–254. doi: 10.1093/genetics/88.2.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hall Ira M., Shankaranarayana Gurumurthy D., Noma Ken-Ichi, Ayoub Nabieh, Cohen Amikam, Grewal Shiv I. S. Establishment and maintenance of a heterochromatin domain. Science. 2002 Sep 5;297(5590):2232–2237. doi: 10.1126/science.1076466. [DOI] [PubMed] [Google Scholar]
  13. Hammond S. M., Boettcher S., Caudy A. A., Kobayashi R., Hannon G. J. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science. 2001 Aug 10;293(5532):1146–1150. doi: 10.1126/science.1064023. [DOI] [PubMed] [Google Scholar]
  14. Hannon Gregory J. RNA interference. Nature. 2002 Jul 11;418(6894):244–251. doi: 10.1038/418244a. [DOI] [PubMed] [Google Scholar]
  15. Huelsenbeck J. P., Ronquist F. MRBAYES: Bayesian inference of phylogenetic trees. Bioinformatics. 2001 Aug;17(8):754–755. doi: 10.1093/bioinformatics/17.8.754. [DOI] [PubMed] [Google Scholar]
  16. Huelsenbeck J. P., Ronquist F., Nielsen R., Bollback J. P. Bayesian inference of phylogeny and its impact on evolutionary biology. Science. 2001 Dec 14;294(5550):2310–2314. doi: 10.1126/science.1065889. [DOI] [PubMed] [Google Scholar]
  17. Jenuwein Thomas. Molecular biology. An RNA-guided pathway for the epigenome. Science. 2002 Sep 27;297(5590):2215–2218. doi: 10.1126/science.1077903. [DOI] [PubMed] [Google Scholar]
  18. Lagos-Quintana M., Rauhut R., Lendeckel W., Tuschl T. Identification of novel genes coding for small expressed RNAs. Science. 2001 Oct 26;294(5543):853–858. doi: 10.1126/science.1064921. [DOI] [PubMed] [Google Scholar]
  19. Lau N. C., Lim L. P., Weinstein E. G., Bartel D. P. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science. 2001 Oct 26;294(5543):858–862. doi: 10.1126/science.1065062. [DOI] [PubMed] [Google Scholar]
  20. Lee R. C., Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science. 2001 Oct 26;294(5543):862–864. doi: 10.1126/science.1065329. [DOI] [PubMed] [Google Scholar]
  21. Letunic Ivica, Goodstadt Leo, Dickens Nicholas J., Doerks Tobias, Schultz Joerg, Mott Richard, Ciccarelli Francesca, Copley Richard R., Ponting Chris P., Bork Peer. Recent improvements to the SMART domain-based sequence annotation resource. Nucleic Acids Res. 2002 Jan 1;30(1):242–244. doi: 10.1093/nar/30.1.242. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Lupton S. D., Brunton L. L., Kalberg V. A., Overell R. W. Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene. Mol Cell Biol. 1991 Jun;11(6):3374–3378. doi: 10.1128/mcb.11.6.3374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Marcotte E. M., Pellegrini M., Ng H. L., Rice D. W., Yeates T. O., Eisenberg D. Detecting protein function and protein-protein interactions from genome sequences. Science. 1999 Jul 30;285(5428):751–753. doi: 10.1126/science.285.5428.751. [DOI] [PubMed] [Google Scholar]
  24. Marcotte E. M., Pellegrini M., Thompson M. J., Yeates T. O., Eisenberg D. A combined algorithm for genome-wide prediction of protein function. Nature. 1999 Nov 4;402(6757):83–86. doi: 10.1038/47048. [DOI] [PubMed] [Google Scholar]
  25. Notredame C., Higgins D. G., Heringa J. T-Coffee: A novel method for fast and accurate multiple sequence alignment. J Mol Biol. 2000 Sep 8;302(1):205–217. doi: 10.1006/jmbi.2000.4042. [DOI] [PubMed] [Google Scholar]
  26. Pellegrini M., Marcotte E. M., Thompson M. J., Eisenberg D., Yeates T. O. Assigning protein functions by comparative genome analysis: protein phylogenetic profiles. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4285–4288. doi: 10.1073/pnas.96.8.4285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Reinhart Brenda J., Bartel David P. Small RNAs correspond to centromere heterochromatic repeats. Science. 2002 Aug 22;297(5588):1831–1831. doi: 10.1126/science.1077183. [DOI] [PubMed] [Google Scholar]
  28. Russo D. A., Petryk A., August C. S. Telomerase activity and phenotypic characterization in harvested bone marrow from a child with a germline cell cancer. Transplant Proc. 1997 Jun;29(4):2002–2002. doi: 10.1016/s0041-1345(97)00204-2. [DOI] [PubMed] [Google Scholar]
  29. Schultz J., Milpetz F., Bork P., Ponting C. P. SMART, a simple modular architecture research tool: identification of signaling domains. Proc Natl Acad Sci U S A. 1998 May 26;95(11):5857–5864. doi: 10.1073/pnas.95.11.5857. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Selker E. U. Premeiotic instability of repeated sequences in Neurospora crassa. Annu Rev Genet. 1990;24:579–613. doi: 10.1146/annurev.ge.24.120190.003051. [DOI] [PubMed] [Google Scholar]
  31. Shiu P. K., Raju N. B., Zickler D., Metzenberg R. L. Meiotic silencing by unpaired DNA. Cell. 2001 Dec 28;107(7):905–916. doi: 10.1016/s0092-8674(01)00609-2. [DOI] [PubMed] [Google Scholar]
  32. Shiu Patrick K. T., Metzenberg Robert L. Meiotic silencing by unpaired DNA: properties, regulation and suppression. Genetics. 2002 Aug;161(4):1483–1495. doi: 10.1093/genetics/161.4.1483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Tabara Hiroaki, Yigit Erbay, Siomi Haruhiko, Mello Craig C. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell. 2002 Jun 28;109(7):861–871. doi: 10.1016/s0092-8674(02)00793-6. [DOI] [PubMed] [Google Scholar]
  34. Volpe Thomas A., Kidner Catherine, Hall Ira M., Teng Grace, Grewal Shiv I. S., Martienssen Robert A. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science. 2002 Aug 22;297(5588):1833–1837. doi: 10.1126/science.1074973. [DOI] [PubMed] [Google Scholar]

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