Skip to main content
PMC home page
Genetics logoLink to Genetics
. 2003 Nov;165(3):1623–1628. doi: 10.1093/genetics/165.3.1623

The EGL-13 SOX domain transcription factor affects the uterine pi cell lineages in Caenorhabditis elegans.

Hediye Nese Cinar 1, Keri L Richards 1, Kavita S Oommen 1, Anna P Newman 1
PMCID: PMC1462816  PMID: 14668410

Abstract

We isolated egl-13 mutants in which the pi cells of the Caenorhabditis elegans uterus initially appeared to develop normally but then underwent an extra round of cell division. The data suggest that egl-13 is required for maintenance of the pi cell fate.

Full Text

The Full Text of this article is available as a PDF (113.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bevan J. C., Reimer E. J., Smith M. F., Scheepers L deV, Bridge H. S., Martin G. R., Bevan D. R. Decreased mivacurium requirements and delayed neuromuscular recovery during sevoflurane anesthesia in children and adults. Anesth Analg. 1998 Oct;87(4):772–778. doi: 10.1097/00000539-199810000-00006. [DOI] [PubMed] [Google Scholar]
  2. Bowles J., Schepers G., Koopman P. Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev Biol. 2000 Nov 15;227(2):239–255. doi: 10.1006/dbio.2000.9883. [DOI] [PubMed] [Google Scholar]
  3. Brenner S. The genetics of Caenorhabditis elegans. Genetics. 1974 May;77(1):71–94. doi: 10.1093/genetics/77.1.71. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cinar H. N., Sweet K. L., Hosemann K. E., Earley K., Newman A. P. The SEL-12 presenilin mediates induction of the Caenorhabditis elegans uterine pi cell fate. Dev Biol. 2001 Sep 1;237(1):173–182. doi: 10.1006/dbio.2001.0374. [DOI] [PubMed] [Google Scholar]
  5. Freyd G., Kim S. K., Horvitz H. R. Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11. Nature. 1990 Apr 26;344(6269):876–879. doi: 10.1038/344876a0. [DOI] [PubMed] [Google Scholar]
  6. Greenwald I. S., Sternberg P. W., Horvitz H. R. The lin-12 locus specifies cell fates in Caenorhabditis elegans. Cell. 1983 Sep;34(2):435–444. doi: 10.1016/0092-8674(83)90377-x. [DOI] [PubMed] [Google Scholar]
  7. Hanna-Rose W., Han M. COG-2, a sox domain protein necessary for establishing a functional vulval-uterine connection in Caenorhabditis elegans. Development. 1999 Jan;126(1):169–179. doi: 10.1242/dev.126.1.169. [DOI] [PubMed] [Google Scholar]
  8. Kimble J., Hirsh D. The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans. Dev Biol. 1979 Jun;70(2):396–417. doi: 10.1016/0012-1606(79)90035-6. [DOI] [PubMed] [Google Scholar]
  9. Newman A. P., Acton G. Z., Hartwieg E., Horvitz H. R., Sternberg P. W. The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells. Development. 1999 Dec;126(23):5319–5326. doi: 10.1242/dev.126.23.5319. [DOI] [PubMed] [Google Scholar]
  10. Newman A. P., Inoue T., Wang M., Sternberg P. W. The Caenorhabditis elegans heterochronic gene lin-29 coordinates the vulval-uterine-epidermal connections. Curr Biol. 2000 Nov 30;10(23):1479–1488. doi: 10.1016/s0960-9822(00)00827-7. [DOI] [PubMed] [Google Scholar]
  11. Newman A. P., Sternberg P. W. Coordinated morphogenesis of epithelia during development of the Caenorhabditis elegans uterine-vulval connection. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9329–9333. doi: 10.1073/pnas.93.18.9329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Newman A. P., White J. G., Sternberg P. W. Morphogenesis of the C. elegans hermaphrodite uterus. Development. 1996 Nov;122(11):3617–3626. doi: 10.1242/dev.122.11.3617. [DOI] [PubMed] [Google Scholar]
  13. Newman A. P., White J. G., Sternberg P. W. The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell. Development. 1995 Feb;121(2):263–271. doi: 10.1242/dev.121.2.263. [DOI] [PubMed] [Google Scholar]
  14. Pevny L. H., Lovell-Badge R. Sox genes find their feet. Curr Opin Genet Dev. 1997 Jun;7(3):338–344. doi: 10.1016/s0959-437x(97)80147-5. [DOI] [PubMed] [Google Scholar]
  15. Sharma-Kishore R., White J. G., Southgate E., Podbilewicz B. Formation of the vulva in Caenorhabditis elegans: a paradigm for organogenesis. Development. 1999 Feb;126(4):691–699. doi: 10.1242/dev.126.4.691. [DOI] [PubMed] [Google Scholar]
  16. Sternberg P. W., Horvitz H. R. Pattern formation during vulval development in C. elegans. Cell. 1986 Mar 14;44(5):761–772. doi: 10.1016/0092-8674(86)90842-1. [DOI] [PubMed] [Google Scholar]
  17. Trent C., Tsuing N., Horvitz H. R. Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics. 1983 Aug;104(4):619–647. doi: 10.1093/genetics/104.4.619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Werner M. H., Huth J. R., Gronenborn A. M., Clore G. M. Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex. Cell. 1995 Jun 2;81(5):705–714. doi: 10.1016/0092-8674(95)90532-4. [DOI] [PubMed] [Google Scholar]

Articles from Genetics are provided here courtesy of Oxford University Press

RESOURCES