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. 2003 Dec;165(4):2295–2299. doi: 10.1093/genetics/165.4.2295

A Sod2 null mutation confers severely reduced adult life span in Drosophila.

Atanu Duttaroy 1, Anirban Paul 1, Mukta Kundu 1, Amy Belton 1
PMCID: PMC1462872  PMID: 14704205

Abstract

A null mutation for the Sod2 gene, Sod2n283, was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sodn283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.

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Selected References

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