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. 1984 Jan;17(1):83–85. doi: 10.1111/j.1365-2125.1984.tb05003.x

Nifedipine increases and glyceryl trinitrate decreases apparent liver blood flow in normal subjects.

J Feely
PMCID: PMC1463307  PMID: 6419762

Abstract

The effects of sublingual nifedipine (10 mg) and of glyceryl trinitrate (500 micrograms), which produce arterial and venous vasodilatation respectively, on indocyanine green estimated apparent liver blood flow (LBF) were studied in six healthy volunteers. Nifedipine significantly increased (33 +/- 12%; mean +/- s.e. mean) and glyceryl trinitrate significantly reduced (18 +/- 3%) LBF. There was a positive relationship (r = 0.92, P less than 0.05) between the reduction in mean arterial pressure produced by nifedipine and the percentage increase in LBF. These results show that single doses of nifedipine and glyceryl trinitrate significantly alter LBF.

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Selected References

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  1. CAESAR J., SHALDON S., CHIANDUSSI L., GUEVARA L., SHERLOCK S. The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function. Clin Sci. 1961 Aug;21:43–57. [PubMed] [Google Scholar]
  2. Daneshmend T. K., Jackson L., Roberts C. J. Physiological and pharmacological variability in estimated hepatic blood flow in man. Br J Clin Pharmacol. 1981 May;11(5):491–496. doi: 10.1111/j.1365-2125.1981.tb01155.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Feely J., Robertson D., Island D. P., Wood A. J. Cimetidine alters plasma catecholamine levels and cortisol and aldosterone excretion. N Engl J Med. 1982 Apr 29;306(17):1054–1054. doi: 10.1056/NEJM198204293061716. [DOI] [PubMed] [Google Scholar]
  4. Feely J., Wade D., McAllister C. B., Wilkinson G. R., Robertson D. Effect of hypotension on liver blood flow and lidocaine disposition. N Engl J Med. 1982 Sep 30;307(14):866–869. doi: 10.1056/NEJM198209303071406. [DOI] [PubMed] [Google Scholar]
  5. George C. F. Drug kinetics and hepatic blood flow. Clin Pharmacokinet. 1979 Nov-Dec;4(6):433–448. doi: 10.2165/00003088-197904060-00003. [DOI] [PubMed] [Google Scholar]
  6. Groszmann R. J., Kravetz D., Bosch J., Glickman M., Bruix J., Bredfeldt J., Conn H. O., Rodes J., Storer E. H. Nitroglycerin improves the hemodynamic response to vasopressin in portal hypertension. Hepatology. 1982 Nov-Dec;2(6):757–762. doi: 10.1002/hep.1840020602. [DOI] [PubMed] [Google Scholar]
  7. Hassan S., Abrams S. M., Turner P. The effect of indoramin infusion on apparent liver blood flow in man. Br J Clin Pharmacol. 1983 May;15(5):576–578. doi: 10.1111/j.1365-2125.1983.tb02097.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Maclean D., Feely J. Calcium antagonists, nitrates, and new antianginal drugs. Br Med J (Clin Res Ed) 1983 Apr 2;286(6371):1127–1130. doi: 10.1136/bmj.286.6371.1127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Magorien R. D., Triffon D. W., Desch C. E., Bay W. H., Unverferth D. V., Leier C. V. Prazosin and hydralazine in congestive heart failure. Regional hemodynamic effects in relation to dose. Ann Intern Med. 1981 Jul;95(1):5–13. doi: 10.7326/0003-4819-95-1-5. [DOI] [PubMed] [Google Scholar]
  10. Pratt J. H., Grim C. E., Parkinson C. A. Minoxidil increases aldosterone metabolic clearance in hypertensive patients. J Clin Endocrinol Metab. 1979 Dec;49(6):834–837. doi: 10.1210/jcem-49-6-834. [DOI] [PubMed] [Google Scholar]
  11. Stenson R. E., Constantino R. T., Harrison D. C. Interrelationships of hepatic blood flow, cardiac output, and blood levels of lidocaine in man. Circulation. 1971 Feb;43(2):205–211. doi: 10.1161/01.cir.43.2.205. [DOI] [PubMed] [Google Scholar]

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