Abstract
1 A solid state activity monitor worn on the wrist was used to study the effect of flunitrazepam, flurazepam, temazepam, triazolam and midazolam.
2 All compounds reduced motor activity in the first half, but only flunitrazepam and flurazepam had an effect during the second half of the bed rest period.
3 Ambulatory activity monitoring is an unobtrusive and simple method for investigating timecourse of action.
Keywords: hypnotics, ambulatory motor activity
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Selected References
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- Borbély A. A., Loepfe M., Mattmann P., Tobler I. Midazolam and triazolam: hypnotic action and residual effects after a single bedtime dose. Arzneimittelforschung. 1983;33(10):1500–1502. [PubMed] [Google Scholar]
- Borbély A. A., Mattmann P., Loepfe M., Fellmann I., Gerne M., Strauch I., Lehmann D. A single dose of benzodiazepine hypnotics alters the sleep EEG in the subsequent drug-free night. Eur J Pharmacol. 1983 Apr 22;89(1-2):157–161. doi: 10.1016/0014-2999(83)90622-2. [DOI] [PubMed] [Google Scholar]
- Borbély A. A., Mattmann P., Loepfe M. Hypnotic action and residual effects of a single bedtime dose of temazepam. Arzneimittelforschung. 1984;34(1):101–103. [PubMed] [Google Scholar]
- Borbély A. A., Neuhaus H. U., Mattmann P., Waser P. G. Langzeitregistrierung der Bewegungsaktivität: Anwendungen in Forschung und Klinik. Schweiz Med Wochenschr. 1981 May 23;111(21):730–735. [PubMed] [Google Scholar]
- Greenblatt D. J., Locniskar A., Ochs H. R., Lauven P. M. Automated gas chromatography for studies of midazolam pharmacokinetics. Anesthesiology. 1981 Aug;55(2):176–179. doi: 10.1097/00000542-198108000-00014. [DOI] [PubMed] [Google Scholar]
- HINTON J. M. The actions of amylobarbitone sodium, butobarbitone and quinalbarbitone sodium upon insomnia and nocturnal restlessness compared in psychiatric patients. Br J Pharmacol Chemother. 1961 Feb;16:82–89. doi: 10.1111/j.1476-5381.1961.tb00300.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- OSWALD I., BERGER R. J., JARAMILLO R. A., KEDDIE K. M., OLLEY P. C., PLUNKETT G. B. Melancholia and barbiturates: a controlled EEG, body and eye movement study of sleep. Br J Psychiatry. 1963 Jan;109:66–78. doi: 10.1192/bjp.109.458.66. [DOI] [PubMed] [Google Scholar]