Skip to main content
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1984;18(Suppl 1):27S–35S. doi: 10.1111/j.1365-2125.1984.tb02580.x

Investigating drug-ethanol interactions

G A Starmer, K D Bird
PMCID: PMC1463345  PMID: 6098293

Abstract

1 Methodology developed in our laboratories for testing the interactive effects of ethanol and drugs on human psychomotor performance is discussed.

2 An attempt has been made to relate the findings of our studies to the results of real-life impairment, particularly in traffic crashes.

3 Proposals for more comprehensive testing of drug-ethnol interactions have been put forward which may increase the predictive value of such tests.

Keywords: ethanol, drugs, human psychomotor performance

Full text

PDF
27S

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Belgrave B. E., Bird K. D., Chesher G. B., Jackson D. M., Lubbe K. E., Starmer G. A., Teo R. K. The effect of cannabidiol, alone and in combination with ethanol, on human performance. Psychopharmacology (Berl) 1979 Aug 8;64(2):243–246. doi: 10.1007/BF00496070. [DOI] [PubMed] [Google Scholar]
  2. Bird K. D., Boleyn T., Chesher G. B., Jackson D. M., Starmer G. A., Teo R. K. Intercannabinoid and cannabinoid-ethanol interactions on human performance. Psychopharmacology (Berl) 1980;71(2):181–188. doi: 10.1007/BF00434409. [DOI] [PubMed] [Google Scholar]
  3. Bird K. D., Chesher G. B., Perl J., Starmer G. A. Naloxone has no effect on ethanol-induced impairment of psychomotor performance in man. Psychopharmacology (Berl) 1982;76(2):193–197. doi: 10.1007/BF00435277. [DOI] [PubMed] [Google Scholar]
  4. Chesher G. B., Franks H. M., Hensley V. R., Hensley W. J., Jackson D. M., Starmer G. A., Teo R. K. The interaction of ethanol and delta9-tetrahydrocannabinol in man: effects on perceptual, cognitive and motor functions. Med J Aust. 1976 Jul 31;2(5):159–163. [PubMed] [Google Scholar]
  5. Chesher G. B., Franks H. M., Jackson D. M., Starmer G. A., Teo R. K. Ethanol and delta9-tetrahydrocannabinol interactive effects on human perceptual, cognitive and motor functions. II. Med J Aust. 1977 Apr 2;1(14):478–481. [PubMed] [Google Scholar]
  6. Crawford W. A., Franks H. M., Hensley V. R., Starmer G. A., Teo R. K. The effect of disodium cromoglycate on human performance, alone and in combination with ethanol. Med J Aust. 1976 Jun 26;1(26):997–999. doi: 10.5694/j.1326-5377.1976.tb128923.x. [DOI] [PubMed] [Google Scholar]
  7. Edwards F., Schabinsky V. V., Jackson D. M., Starmer G. A., Jenkins O. Involvement of catecholamines in acute tolerance to ethanol in mice. Psychopharmacology (Berl) 1983;79(2-3):246–250. doi: 10.1007/BF00427821. [DOI] [PubMed] [Google Scholar]
  8. Franks H. M., Hagedorn H., Hensley V. R., Hensley W. J., Starmer G. A. The effect of caffeine on human performance, alone and in combination with ethanol. Psychopharmacologia. 1975 Dec 31;45(2):177–181. doi: 10.1007/BF00429058. [DOI] [PubMed] [Google Scholar]
  9. Franks H. M., Hagedorn H., Hensley V. R., Hensley W. J., Starmer G. A. The interaction of fructose, dextrose and ethanol on human performance. Clin Exp Pharmacol Physiol. 1977 Mar-Apr;4(2):153–163. doi: 10.1111/j.1440-1681.1977.tb02615.x. [DOI] [PubMed] [Google Scholar]
  10. Franks H. M., Hensley V. R., Hensley W. J., Starmer G. A., Teo R. K. The interaction between ethanol and antihistamines. 1: Dexchlorpheniramine. Med J Aust. 1978 Apr 22;1(8):449–452. [PubMed] [Google Scholar]
  11. Franks H. M., Hensley V. R., Hensley W. J., Starmer G. A., Teo R. K. The interaction between ethanol and antihistamines: 2. Clemastine. Med J Aust. 1979 Mar 10;1(5):185–186. doi: 10.5694/j.1326-5377.1979.tb128984.x. [DOI] [PubMed] [Google Scholar]
  12. Franks H. M., Hensley V. R., Hensley W. J., Starmer G. A., Teo R. K. The relationship between alcohol dosage and performance decrement in humans. J Stud Alcohol. 1976 Mar;37(3):284–297. doi: 10.15288/jsa.1976.37.284. [DOI] [PubMed] [Google Scholar]
  13. Franks H. M., Lawrie M., Schabinsky V. V., Starmer G. A., Teo R. K. Interaction between ethanol and antihistamines: 3. mebhydrolin. Med J Aust. 1981 Oct 31;2(9):477–479. doi: 10.5694/j.1326-5377.1981.tb112944.x. [DOI] [PubMed] [Google Scholar]
  14. Greizerstein H. B. Congener contents of alcoholic beverages. J Stud Alcohol. 1981 Nov;42(11):1030–1037. doi: 10.15288/jsa.1981.42.1030. [DOI] [PubMed] [Google Scholar]
  15. Leigh G., Tong J. E., Campbell J. A. Effects of ethanol and tobacco on divided attention. J Stud Alcohol. 1977 Jul;38(7):1233–1239. doi: 10.15288/jsa.1977.38.1233. [DOI] [PubMed] [Google Scholar]
  16. Linnoila M. Effect of drugs and alcohol on psychomotor skills related to driving. Ann Clin Res. 1974 Feb;6(1):7–18. [PubMed] [Google Scholar]
  17. Martin N. G., Gibson J. B., Oakeshott J. G., Wilks A. V., Starmer G. A., Craig J., Perl J. A twin study of psychomotor performance during alcohol intoxication: early results. Prog Clin Biol Res. 1981;69(Pt 100):89–96. [PubMed] [Google Scholar]
  18. Perl J., Starmer G. A. Lowered blood ethanol concentrations after a sugar-based drink. Med J Aust. 1983 Jun 25;1(13):600–600. doi: 10.5694/j.1326-5377.1983.tb136237.x. [DOI] [PubMed] [Google Scholar]
  19. Sternberg S. High-speed scanning in human memory. Science. 1966 Aug 5;153(3736):652–654. doi: 10.1126/science.153.3736.652. [DOI] [PubMed] [Google Scholar]
  20. Sternberg S. Memory-scanning: mental processes revealed by reaction-time experiments. Am Sci. 1969 Winter;57(4):421–457. [PubMed] [Google Scholar]
  21. de Gier J. J., 't Hart B. J., Nelemans F. A., Bergman H. Psychomotor performance and real driving performance of outpatients receiving diazepam. Psychopharmacology (Berl) 1981;73(4):340–344. doi: 10.1007/BF00426462. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES