Abstract
The effect of urinary pH on flecainide excretion has been evaluated in six healthy subjects after a single oral dose of 300 mg flecainide administered as the acetate salt. The cumulative urinary excretion of unchanged flecainide under acidic conditions (134.0 +/- 16.1 mg; mean +/- s.e. mean) was significantly higher than under alkaline conditions (22.3 +/- 7.6 mg; mean +/- s.e. mean) (P less than 0.01). Under alkaline conditions, tmax (time to reach peak concentration) was reduced (P less than 0.01), while elimination half-life, AUC(0-32) and AUC(0-infinity) were increased (P less than 0.01).
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- Banitt E. H., Bronn W. R., Coyne W. E., Schmid J. R. Antiarrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides. J Med Chem. 1977 Jun;20(6):821–826. doi: 10.1021/jm00216a016. [DOI] [PubMed] [Google Scholar]
- Beckett A. H., Triggs E. J. Buccal absorption of basic drugs and its application as an in vivo model of passive drug transfer through lipid membranes. J Pharm Pharmacol. 1967 Dec;19(Suppl):31S–41S. [PubMed] [Google Scholar]
- Duff H. J., Roden D. M., Maffucci R. J., Vesper B. S., Conard G. J., Higgins S. B., Oates J. A., Smith R. F., Woosley R. L. Suppression of resistant ventricular arrhythmias by twice daily dosing with flecainide. Am J Cardiol. 1981 Dec;48(6):1133–1140. doi: 10.1016/0002-9149(81)90331-3. [DOI] [PubMed] [Google Scholar]
- Duran D., Platia E. V., Griffith L. S., Adhar G., Reid P. R. Suppression of complex ventricular arrhythmias by oral flecainide. Clin Pharmacol Ther. 1982 Nov;32(5):554–561. doi: 10.1038/clpt.1982.202. [DOI] [PubMed] [Google Scholar]
- Hodges M., Haugland J. M., Granrud G., Conard G. J., Asinger R. W., Mikell F. L., Krejci J. Suppression of ventricular ectopic depolarizations by flecainide acetate, a new antiarrhythmic agent. Circulation. 1982 May;65(5):879–885. doi: 10.1161/01.cir.65.5.879. [DOI] [PubMed] [Google Scholar]
- Johnston A., Burgess C. D., Warrington S. J., Wadsworth J., Hamer N. A. The effect of spontaneous changes in urinary pH on mexiletine plasma concentrations and excretion during chronic administration to healthy volunteers. Br J Clin Pharmacol. 1979 Oct;8(4):349–352. doi: 10.1111/j.1365-2125.1979.tb04717.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Johnston A., Woollard R. C. STRIPE: an interactive computer program for the analysis of drug pharmacokinetics. J Pharmacol Methods. 1983 May;9(3):193–199. doi: 10.1016/0160-5402(83)90038-4. [DOI] [PubMed] [Google Scholar]
- Meyer W., Kaye C. M., Turner P. A study of the influence of pH on the buccal absorption and renal excretion of procainamide. Eur J Clin Pharmacol. 1974 Jul 26;7(4):287–289. doi: 10.1007/BF00560346. [DOI] [PubMed] [Google Scholar]