Abstract
The hypnotic efficacy of temazepam capsules (30 mg) was studied in twelve patients who had objective polysomnographic evidence of sleep onset insomnia. Patients slept in the laboratory, retiring at their usual bedtime after taking placebo or temazepam 30 min earlier, and were monitored for 8 h using standard polysomnographic techniques. Acute (nights 5-7) and chronic (nights 11-13) temazepam improved the sleep of these patients by reducing sleep latency and increasing sleep time compared to the placebo baseline (nights 2-4). No detrimental effects on daytime function the following morning were observed using questionnaires and objective tests of performance. No consistent evidence of disturbed sleep after discontinuation of treatment was obtained over three recovery nights.
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Selected References
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- Bixler E. O., Kales A., Soldatos C. R., Scharf M. B., Kales J. D. Effectiveness of temazepam with short-intermediate-, and long-term use: sleep laboratory evaluation. J Clin Pharmacol. 1978 Feb-Mar;18(2-3):110–118. doi: 10.1002/j.1552-4604.1978.tb02430.x. [DOI] [PubMed] [Google Scholar]
- Fillingim J. M. Double-blind evaluation of temazepam, flurazepam, and placebo in geriatric insomniacs. Clin Ther. 1982;4(5):369–380. [PubMed] [Google Scholar]
- Fillingim J. M. Double-blind evaluation of the efficacy and safety of temazepam in outpatients with insomnia. Br J Clin Pharmacol. 1979;8(1):73S–77S. doi: 10.1111/j.1365-2125.1979.tb00461.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heffron W. A., Roth P. Double-blind evaluation of the safety and hypnotic efficacy of temazepam in insomniac outpatients. Br J Clin Pharmacol. 1979;8(1):69S–72S. doi: 10.1111/j.1365-2125.1979.tb00460.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mitler M. M., Carskadon M. A., Phillips R. L., Sterling W. R., Zarcone V. P., Jr, Spiegel R., Guilleminault C., Dement W. C. Hypnotic efficacy of temazepam: a long-term sleep laboratory evaluation. Br J Clin Pharmacol. 1979;8(1):63S–68S. doi: 10.1111/j.1365-2125.1979.tb00459.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mitler M. M. Evaluation of temazepam as a hypnotic. Pharmacotherapy. 1981 Jul-Aug;1(1):3–13. doi: 10.1002/j.1875-9114.1981.tb03546.x. [DOI] [PubMed] [Google Scholar]
- Nicholson A. N., Stone B. M. Diazepam and 3-hydroxydiazepam (temazepam) and sleep of middle age. Br J Clin Pharmacol. 1979 May;7(5):463–468. doi: 10.1111/j.1365-2125.1979.tb00987.x. [DOI] [PMC free article] [PubMed] [Google Scholar]