Abstract
Ten male patients with chronic stable angina pectoris completed a randomized, double-blind cross-over study, with matched placebo run-in period (P), to compare the effects of a long-acting preparation of propranolol (LA, 160 mg once a day) with that of conventional propranolol (CP, 40 mg four times a day) each given for 14 days. Response was assessed by symptom-limited bicycle ergometry, degree of ST segment depression, daily anginal attack rate and glyceryl trinitrin consumption (GTN). Heart rate and ventricular extra-systolic frequency (VES) were recorded by 24 h Holter monitor. Bicycle ergometry was performed and a trough blood sample taken for propranolol estimation on day 14 prior to the morning dose. Both formulations increased total work capacity (P 3412, LA 4095, CP 3697 kpm/min), reduced rate-pressure product (P 21896, LA 16011, CP 15609 mm Hg beats/min), and degree of ST segment depression (P 4.53, LA 2.48, CP 2.43), but without differences between the formulations. Daily anginal attack rate was reduced from 30 (placebo) to 7.5 (CP) and 14.5 (LA) (P less than 0.05 between treatment groups). There was a reduction in daily GTN consumption by both treatments. The heart rate and total number of VESs during 24 h was similar in the two treatment groups and was reduced in comparison with placebo. Both formulations were well tolerated. Long-acting propranolol is an effective and well-tolerated alternative to conventional propranolol in the treatment of chronic stable and stress-induced angina, and in reducing VES frequency.
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Selected References
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- GILLAM P. M., PRICHARD B. N. USE OF PROPRANOLOL IN ANGINA PECTORIS. Br Med J. 1965 Aug 7;2(5457):337–339. doi: 10.1136/bmj.2.5457.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McIlmoyle E. L., Blair A. L., Calvert H. W., Boyle D. M., Shanks R. G., Leahey W., Barber J. M. Studies with a slow-release formulation of propranolol in angina. Ir Med J. 1979 Jan 12;72(1):27–28. [PubMed] [Google Scholar]
- Parker J. O., Porter A., Parker J. D. Propranolol in angina pectoris. Comparison of long-acting and standard-formulation propranolol. Circulation. 1982 Jun;65(7):1351–1355. doi: 10.1161/01.cir.65.7.1351. [DOI] [PubMed] [Google Scholar]
- Prichard B. N. Propranolol in the treatment of angina: a review. Postgrad Med J. 1976;52 (Suppl 4):35–41. [PubMed] [Google Scholar]
- Schäfer M., Geissler H. E., Mutschler E. Fluorimetrische Bestimmung von Propranolol und seines Metaboliten N-Desisopropylpropranolol in Plasma und Urin durch direkte Auswertung von Dünnschichtchromatogrammen. J Chromatogr. 1977 Nov 1;143(6):607–613. [PubMed] [Google Scholar]
- Thadani U., Parker J. O. Propranolol in angina pectoris: comparison of therapy given two and four times daily. Am J Cardiol. 1980 Jul;46(1):117–123. doi: 10.1016/0002-9149(80)90613-x. [DOI] [PubMed] [Google Scholar]
- Thadani U., Sharma B., Meeran M. K., Majid P. A., Whitaker W., Taylor S. H. Comparison of adrenergic beta-receptor antagonists in angina pectoris. Br Med J. 1973 Jan 20;1(5846):138–142. doi: 10.1136/bmj.1.5846.138. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wolfson S., Heinle R. A., Herman M. V., Kemp H. G., Sullivan J. M., Gorlin R. Propranolol and angina pectoris. Am J Cardiol. 1966 Sep;18(3):345–353. doi: 10.1016/0002-9149(66)90052-x. [DOI] [PubMed] [Google Scholar]