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. 1984 May;17(5):525–530. doi: 10.1111/j.1365-2125.1984.tb02385.x

Influence of chronic dosing on theophylline clearance.

H Efthimiou, D J Morgan, L Ioannides-Demos, K Raymond, A J McLean
PMCID: PMC1463460  PMID: 6733000

Abstract

Theophylline clearance was studied in normal healthy volunteers before and after chronic oral dosing. Oral theophylline clearance showed a significant decrease (P less than 0.001) from 59.3 +/- 6.48 ml/min (mean +/- s.e. mean, n = 10) to 48.0 +/- 6.4 ml/min. Steady-state intravenous clearance decreased by 26 +/- 2% from 55.1 +/- 7.7 ml/min to 41.0 +/- 5.96 ml/min (mean +/- s.e. mean, n = 6; P less than 0.001) at constant steady-state intravenous test concentrations (mean 15.0 +/- 1.6 micrograms/ml after chronic oral dosing), excluding significant concentration dependence. Extrapolation of acute clearance findings to maintenance requirement may not be valid even in the same individual, with theophylline therapy requiring on-going review beyond acute stabilisation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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