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. 1984;18(Suppl 2):209S–214S. doi: 10.1111/j.1365-2125.1984.tb02600.x

Effect of converting enzyme inhibition by enalapril on sodium homeostasis in the rat

B Jover, A Mimran
PMCID: PMC1463485  PMID: 6099736

Abstract

1 The effect of oral treatment with the converting enzyme inhibitor enalapril on sodium homeostasis was investigated in the rat.

2 Treatment by enalapril prior to and during a 6 day period following abrupt suppression of dietary Na+ was associated with a sodium wasting state (urinary Na+ always exceeded intake during the observation period) and blunting by 90% of the aldosterone response to Na+ restriction

3 In rats on chronic low Na+ intake, enalapril produced a slight, transient natriuresis together with a marked increase in drinking volume.

4 In Na+ replete rats, enalapril had no influence on sodium balance.

5 Converting enzyme inhibition markedly impaired the systemic and renal response to Na restriction and enalapril had no natriuretic effect in the Na+ replete state.

Keywords: converting enzyme inhibition, enalapril, sodium, homeostasis

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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