Abstract
Ten patients with mild to moderate hypertension were treated for 9 weeks with a tablet formulation of pinacidil. Mean supine blood pressure fell from 174/100 to 148/84 mm Hg and mean supine pulse increased by 3 beats/min. Daily dosage was 40-100 mg, given in two or three divided doses. Plasma urea increased significantly and mean weight increased by 1.1 kg. Side effects were frequent but mild, in the main being those typically associated with potent vasodilator drugs. No patient withdrew from the study, and all achieved target blood pressure.
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Selected References
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- Carlsen J. E., Kardel T., Hilden T., Tangø M., Trap-Jensen J. Immediate central and peripheral haemodynamic effects of a new vasodilating agent Pinacidil (P1134) in hypertensive man. Clin Physiol. 1981 Aug;1(4):375–384. doi: 10.1111/j.1475-097x.1981.tb00905.x. [DOI] [PubMed] [Google Scholar]
- Carlsen J. E., Kardel T., Jensen H. A., Tangø M., Trap-Jensen J. Pinacidil, a new vasodilator: pharmacokinetics and pharmacodynamics of a new retarded release tablet in essential hypertension. Eur J Clin Pharmacol. 1983;25(4):557–561. doi: 10.1007/BF00542128. [DOI] [PubMed] [Google Scholar]
- Eilertsen E., Hart J. W., Magnussen M. P., Sørensen H., Arrigoni-Martelli E. Pharmacokinetics and distribution of the new antihypertensive agent pinacidil in rat, dog and man. Xenobiotica. 1982 Mar;12(3):177–185. doi: 10.3109/00498258209046792. [DOI] [PubMed] [Google Scholar]
- Ramsay L. E., Freestone S. Preliminary evaluation of pinacidil in hypertension. Br J Clin Pharmacol. 1983 Sep;16(3):336–338. doi: 10.1111/j.1365-2125.1983.tb02171.x. [DOI] [PMC free article] [PubMed] [Google Scholar]