Abstract
Graded intravenous isoprenaline infusions produce dose-related increases in finger tremor. The dose-response curves constructed with intra-arterial or intravenous isoprenaline behave similarly in the presence of both atenolol 50 mg and propranolol 40 mg. In Five subjects, practolol 120 mg, atenolol 50 mg, propranolol 40 mg and sotalol 200 mg reduced exercise heart rate by 20.2 +/- 2.3, 21.4 +/- 1.8, 17.4 +/- 2.5, 23.9 +/- 3.6% respectively: the differences were not significant. The corresponding dose-ratios for reduction of an isoprenaline tachycardia were 2.8, 2.3, 19.1 and 16.9 respectively. At doses which had comparable effects on an exercise tachycardia, the non-selective beta-adrenoceptor antagonists, propranolol 40 mg and sotalol 200 mg, attenuated the finger response to isoprenaline (dose ratios 33.3 and greater than 25.0 respectively) more than the beta 1-selective adrenoceptor antagonists, practolol 120 mg and atenolol 50 mg (dose ratios 1.0 and 2.3 respectively). In two out of five subjects, dose-response curves could not be constructed with sotalol, either at a dose of 200 or 100 mg. The enhancement of physiological finger tremor by intravenous infusions of isoprenaline may be useful in the investigation of beta 2-adrenoceptors and their antagonists in man.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ablad B., Carlsson B., Carlsson E., Dahlöf C., Ek L., Hultberg E. Cardiac effects of beta-adrenergic receptor antagonists. Adv Cardiol. 1974;12(0):290–302. doi: 10.1159/000395473. [DOI] [PubMed] [Google Scholar]
- Arnold J. M., McDevitt D. G. An assessment of physiological finger tremor as an indicator of beta-adrenoceptor function. Br J Clin Pharmacol. 1983 Aug;16(2):167–174. doi: 10.1111/j.1365-2125.1983.tb04981.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Arnold J. M., McDevitt D. G. Contribution of the vagus to the haemodynamic responses following intravenous boluses of isoprenaline. Br J Clin Pharmacol. 1983 Apr;15(4):423–429. doi: 10.1111/j.1365-2125.1983.tb01525.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Arnold J. M., McDevitt D. G. Heart rate and blood pressure responses to intravenous boluses of isoprenaline in the presence of propranolol, practolol and atropine. Br J Clin Pharmacol. 1983 Aug;16(2):175–184. doi: 10.1111/j.1365-2125.1983.tb04982.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Larsson S., Svedmyr N. Tremor caused by sympathomimetics is mediated by beta2-adrenoreceptors. Scand J Respir Dis. 1977;58(1):5–10. [PubMed] [Google Scholar]
- Marsden C. D., Foley T. H., Owen D. A., McAllister R. G. Peripheral beta-adrenergic receptors concerned with tremor. Clin Sci. 1967 Aug;33(1):53–65. [PubMed] [Google Scholar]
- Perucca E., Pickles H., Richens A. Effect of atenolol, metoprolol, and propranolol on isoproterenol-induced tremor and tachycardia in normal subjects. Clin Pharmacol Ther. 1981 Apr;29(4):425–433. doi: 10.1038/clpt.1981.59. [DOI] [PubMed] [Google Scholar]
- Pickles H., Perucca E., Fish A., Richens A. Propranolol and sotalol as antagonists of isoproterenol-enhanced physiologic tremor. Clin Pharmacol Ther. 1981 Sep;30(3):303–310. doi: 10.1038/clpt.1981.164. [DOI] [PubMed] [Google Scholar]
- Thiringer G., Svedmyr N. Evaluation of skeletal muscle tremor due to bronchodilator agents. Scand J Respir Dis. 1975 Aug;56(2):93–102. [PubMed] [Google Scholar]