Abstract
The blood levels in 20 patients were studied during the change from parenteral administration of disopyramide to an oral sustained release preparation containing the same active substance. From this study it is concluded that 100 mg i.v. bolus injection of disopyramide can safely be followed by the immediate administration of one sustained release tablet containing 250 mg disopyramide. In case of an i.v. infusion (0.4 mg kg-1h-1) it seems wise not to start earlier with the administration of the sustained release preparation than at the moment of stopping the infusion.
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Selected References
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- Heel R. C., Brogden R. N., Speight T. M., Avery G. S. Disopyramide: a review of its pharmacological properties and therapeutic use in treating cardiac arrhythmias. Drugs. 1978 May;15(5):331–368. [PubMed] [Google Scholar]
- Lien E., Bakke O. M. Sustained release disopyramide compared to plain capsules after change-over from intravenous infusion. Br J Clin Pharmacol. 1983 Jul;16(1):71–76. doi: 10.1111/j.1365-2125.1983.tb02146.x. [DOI] [PMC free article] [PubMed] [Google Scholar]