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. 1984 Nov;18(5):802–805. doi: 10.1111/j.1365-2125.1984.tb02547.x

Nicotine from cigarette smoking enhances clonidine-induced increase of serum growth hormone concentrations in men.

V Coiro, L d'Amato, E Borciani, G Rossi, L Camellini, M L Maffei, D Pignatti, P Chiodera
PMCID: PMC1463553  PMID: 6508989

Abstract

In order to determine whether nicotine exerts its stimulant effect on serum concentrations of growth hormone (GH) by interacting with an adrenergic pathway, we evaluated the effect of cigarette smoking on the response of GH to the administration of clonidine, a specific alpha-adrenoceptor agonist. In six normal volunteers, clonidine significantly increased serum levels of GH. When subjects smoked two non-filter cigarettes, GH response to the alpha-adrenoceptor agonist was greatly enhanced. These findings suggest that in man nicotinic cholinergic and adrenergic mechanisms might interact in the stimulation of GH secretion.

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Selected References

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