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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1984 Jul;18(1):86–89. doi: 10.1111/j.1365-2125.1984.tb05026.x

Comparison of pseudoephedrine and triprolidine, alone and in combination in preventing nasal congestion in subjects with allergic rhinitis using nasal histamine challenge.

D W Empey, M F Frosolono, D T Hughes, J G Perkins
PMCID: PMC1463593  PMID: 6204666

Abstract

The abilities of triprolidine 2.5 mg and pseudoephedrine 60 mg, alone and in combination, to protect against an increase in nasal airway resistance (NAR) after histamine challenge were determined in eighteen individuals with grass pollen allergy. The study was conducted outside the pollen season using a double-blind, placebo controlled crossover design. The prior administration of pseudoephedrine 60 mg and triprolidine 2.5 mg alone or in combination was superior to placebo in reducing the increase in NAR after challenge with 1.0% histamine. However, such NAR measurements did not differentiate between pseudoephedrine 60 mg and triprolidine 2.5 mg administered alone or in combination. Challenge with 0.1% histamine failed to discriminate between any of the test medications.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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