Skip to main content
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1984 Oct;18(4):624–626. doi: 10.1111/j.1365-2125.1984.tb02516.x

Cimetidine does not alter ibuprofen kinetics after a single dose.

K A Conrad, M Mayersohn, M Bliss
PMCID: PMC1463611  PMID: 6487504

Abstract

Cimetidine does not slow the disappearance of ibuprofen from the serum after a single dose in healthy male volunteers. This suggests that no change in ibuprofen dosing is necessary when cimetidine is co-administered.

Full text

PDF
624

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Feely J., Wilkinson G. R., Wood A. J. Reduction of liver blood flow and propranolol metabolism by cimetidine. N Engl J Med. 1981 Mar 19;304(12):692–695. doi: 10.1056/NEJM198103193041202. [DOI] [PubMed] [Google Scholar]
  2. Lockwood G. F., Albert K. S., Gillespie W. R., Bole G. G., Harkcom T. M., Szpunar G. J., Wagner J. G. Pharmacokinetics of ibuprofen in man. I. Free and total area/dose relationships. Clin Pharmacol Ther. 1983 Jul;34(1):97–103. doi: 10.1038/clpt.1983.136. [DOI] [PubMed] [Google Scholar]
  3. Lockwood G. F., Wagner J. G. High-performance liquid chromatographic determination of ibuprofen and its major metabolites in biological fluids. J Chromatogr. 1982 Nov 12;232(2):335–343. doi: 10.1016/s0378-4347(00)84173-0. [DOI] [PubMed] [Google Scholar]
  4. Mann N. S., Sachdev A. J. Acute erosive gastritis induced by aspirin, ketoprofen, ibuprofen, and naproxen: its prevention by metiamide and cimetidine. South Med J. 1977 May;70(5):562–564. doi: 10.1097/00007611-197705000-00017. [DOI] [PubMed] [Google Scholar]
  5. Mills R. F., Adams S. S., Cliffe E. E., Dickinson W., Nicholson J. S. The metabolism of ibuprofen. Xenobiotica. 1973 Sep;3(9):589–598. doi: 10.3109/00498257309151547. [DOI] [PubMed] [Google Scholar]
  6. Mojaverian P., Fedder I. L., Vlasses P. H., Rotmensch H. H., Rocci M. L., Jr, Swanson B. N., Ferguson R. K. Cimetidine does not alter morphine disposition in man. Br J Clin Pharmacol. 1982 Dec;14(6):809–813. doi: 10.1111/j.1365-2125.1982.tb02041.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. O'Laughlin J. C., Silvoso G. R., Ivey K. J. Healing of aspirin-associated peptic ulcer disease despite continued salicylate ingestion. Arch Intern Med. 1981 May;141(6):781–783. [PubMed] [Google Scholar]
  8. Sorkin E. M., Darvey D. L. Review of cimetidine drug interactions. Drug Intell Clin Pharm. 1983 Feb;17(2):110–120. doi: 10.1177/106002808301700205. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES