Abstract
GIF-DB (Gene Interactions in the Fly Database) is a new WWW database (http://www-biol.univ-mrs.fr/ approximately lgpd/GIFTS_home_page. html ) describing gene molecular interactions involved in the process of embryonic pattern formation in the flyDrosophila melanogaster. The detailed information is distributed in specific lines arranged into an EMBL- (or SWISS-PROT-) like format. GIF-DB achieves a high level of integration with other databases such as FlyBase, EMBL and SWISS-PROT through numerous hyperlinks. The original concept of interaction databases examplified by GIF-DB could be extended to other biological subjects and organisms so as to study gene regulatory networks in an evolutionary perspective.
Full Text
The Full Text of this article is available as a PDF (138.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alexandre E., Graba Y., Fasano L., Gallet A., Perrin L., De Zulueta P., Pradel J., Kerridge S., Jacq B. The Drosophila teashirt homeotic protein is a DNA-binding protein and modulo, a HOM-C regulated modifier of variegation, is a likely candidate for being a direct target gene. Mech Dev. 1996 Oct;59(2):191–204. doi: 10.1016/0925-4773(96)00594-1. [DOI] [PubMed] [Google Scholar]
- Bairoch A., Apweiler R. The SWISS-PROT protein sequence data bank and its new supplement TREMBL. Nucleic Acids Res. 1996 Jan 1;24(1):21–25. doi: 10.1093/nar/24.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Benson D. A., Boguski M., Lipman D. J., Ostell J. GenBank. Nucleic Acids Res. 1996 Jan 1;24(1):1–5. doi: 10.1093/nar/24.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bertuccioli C., Fasano L., Jun S., Wang S., Sheng G., Desplan C. In vivo requirement for the paired domain and homeodomain of the paired segmentation gene product. Development. 1996 Sep;122(9):2673–2685. doi: 10.1242/dev.122.9.2673. [DOI] [PubMed] [Google Scholar]
- Fasano L., Röder L., Coré N., Alexandre E., Vola C., Jacq B., Kerridge S. The gene teashirt is required for the development of Drosophila embryonic trunk segments and encodes a protein with widely spaced zinc finger motifs. Cell. 1991 Jan 11;64(1):63–79. doi: 10.1016/0092-8674(91)90209-h. [DOI] [PubMed] [Google Scholar]
- George D. G., Barker W. C., Mewes H. W., Pfeiffer F., Tsugita A. The PIR-International Protein Sequence Database. Nucleic Acids Res. 1996 Jan 1;24(1):17–20. doi: 10.1093/nar/24.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Graba Y., Aragnol D., Laurenti P., Garzino V., Charmot D., Berenger H., Pradel J. Homeotic control in Drosophila; the scabrous gene is an in vivo target of Ultrabithorax proteins. EMBO J. 1992 Sep;11(9):3375–3384. doi: 10.1002/j.1460-2075.1992.tb05416.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karp P. D., Riley M., Paley S. M., Pelligrini-Toole A. EcoCyc: an encyclopedia of Escherichia coli genes and metabolism. Nucleic Acids Res. 1996 Jan 1;24(1):32–39. doi: 10.1093/nar/24.1.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lewis E. B. A gene complex controlling segmentation in Drosophila. Nature. 1978 Dec 7;276(5688):565–570. doi: 10.1038/276565a0. [DOI] [PubMed] [Google Scholar]
- Nüsslein-Volhard C., Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature. 1980 Oct 30;287(5785):795–801. doi: 10.1038/287795a0. [DOI] [PubMed] [Google Scholar]
- Rice C. M., Fuchs R., Higgins D. G., Stoehr P. J., Cameron G. N. The EMBL data library. Nucleic Acids Res. 1993 Jul 1;21(13):2967–2971. doi: 10.1093/nar/21.13.2967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Röder L., Vola C., Kerridge S. The role of the teashirt gene in trunk segmental identity in Drosophila. Development. 1992 Aug;115(4):1017–1033. doi: 10.1242/dev.115.4.1017. [DOI] [PubMed] [Google Scholar]
- Wingender E., Dietze P., Karas H., Knüppel R. TRANSFAC: a database on transcription factors and their DNA binding sites. Nucleic Acids Res. 1996 Jan 1;24(1):238–241. doi: 10.1093/nar/24.1.238. [DOI] [PMC free article] [PubMed] [Google Scholar]