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. 1984 Sep;18(3):449–452. doi: 10.1111/j.1365-2125.1984.tb02488.x

Thiazide-induced hypokalaemia; prevalence higher in women.

J M Toner, L E Ramsay
PMCID: PMC1463655  PMID: 6487484

Abstract

In 193 hypertensive patients taking bendrofluazide 5 mg daily, the mean serum potassium concentration was lower in women than in men (3.77 vs 3.99 mmol/l, P less than 0.001) and the prevalence of hypokalaemia (less than 3.5 mmol/l) was higher (25% vs 12%, P less than 0.05). This difference between the sexes was independent of age, body weight, renal function, the use of other antihypertensive drugs and compliance with treatment as judged by tablet counts. Severe hypokalaemia (less than 3.0 mmol/l) was uncommon and showed no difference between the sexes.

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Selected References

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  1. Anderson J., Godfrey B. E., Hill D. M., Munro-Faure A. D., Sheldon J. A comparison of the effects of hydrochlorothiazide and of frusemide in the treatment of hypertensive patients. Q J Med. 1971 Oct;40(160):541–560. [PubMed] [Google Scholar]
  2. COLWILL J. M., DUTTON A. M., MORRISSEY J., YU P. N. ALPHA-METHYLDOPA AND HYDROCHLOROTHIAZIDE. A CONTROLLED STUDY OF THEIR COMPARATIVE EFFECTIVENESS AS ANTIHYPERTENSIVE AGENTS. N Engl J Med. 1964 Oct 1;271:696–703. doi: 10.1056/NEJM196410012711402. [DOI] [PubMed] [Google Scholar]
  3. Clark B. G., Wheatley R., Rawlings J. L., Vestal R. E. Female preponderance in diuretic-associated hypokalemia: a retrospective study in seven long-term care facilities. J Am Geriatr Soc. 1982 May;30(5):316–321. doi: 10.1111/j.1532-5415.1982.tb05620.x. [DOI] [PubMed] [Google Scholar]
  4. Hettiarachchi J., Ramsay L. E., Davies D. L., Fraser R., Watson W. S. Amelioration of bendrofluazide-induced hypokalemia by timolol. Clin Pharmacol Ther. 1977 Jul;22(1):58–62. doi: 10.1002/cpt197722158. [DOI] [PubMed] [Google Scholar]
  5. Jackson P. R., Ramsay L. E., Wakefield V. Relative potency of spironolactone, triamterene and potassium chloride in thiazide-induced hypokalaemia. Br J Clin Pharmacol. 1982 Aug;14(2):257–263. doi: 10.1111/j.1365-2125.1982.tb01970.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Krakauer R., Lauritzen M. Diuretic therapy and hypokalemia in geriatric out-patients. Dan Med Bull. 1978 Apr;25(3):126–129. [PubMed] [Google Scholar]
  7. Lawson D. H., Henry D. A., Lowe J. M., Gray J. M., Morgan H. G. Severe hypokalemia in hospitalized patients. Arch Intern Med. 1979 Sep;139(9):978–980. [PubMed] [Google Scholar]
  8. Morgan D. B., Davidson C. Hypokalaemia and diuretics: an analysis of publications. Br Med J. 1980 Mar 29;280(6218):905–908. doi: 10.1136/bmj.280.6218.905. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Morgan D. B., Young R. M. Acute transient hypokalaemia: new interpretation of a common event. Lancet. 1982 Oct 2;2(8301):751–752. doi: 10.1016/s0140-6736(82)90930-8. [DOI] [PubMed] [Google Scholar]
  10. Nordrehaug J. E., von der Lippe G. Hypokalaemia and ventricular fibrillation in acute myocardial infarction. Br Heart J. 1983 Dec;50(6):525–529. doi: 10.1136/hrt.50.6.525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ramsay L. E., Boyle P., Ramsay M. H. Factors influencing serum potassium in treated hypertension. Q J Med. 1977 Oct;46(184):401–410. [PubMed] [Google Scholar]
  12. Ramsay L. E., Hettiarachchi J., Fraser R., Morton J. J. Amiloride, spironolactone, and potassium chloride in thiazide-treated hypertensive patients. Clin Pharmacol Ther. 1980 Apr;27(4):533–543. doi: 10.1038/clpt.1980.75. [DOI] [PubMed] [Google Scholar]

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