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. 1984 Dec;18(6):849–852. doi: 10.1111/j.1365-2125.1984.tb02554.x

Propranolol concentrations in blood serum, seminal plasma and saliva in man after a single oral dose.

P Mahajan, E D Grech, R M Pearson, E J Ridgway, P Turner
PMCID: PMC1463698  PMID: 6529524

Abstract

A single dose of 80 mg racemic propranolol hydrochloride was administered by mouth to six healthy male volunteers. The mean concentration achieved in seminal plasma at 2 h after dosing was almost identical to that in blood serum. The concentrations of propranolol in seminal plasma and saliva were much less than those known to reduce sperm motility by 50% in vitro. The concentrations in saliva did not reflect those in blood serum. Propranolol in the dose administered in this study is unlikely to affect fertility by its presence in saliva or semen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alván G., Bergström K., Borgå O., Iselius L., Pedersen N. Family study of genetic and environmental factors determining the protein binding of propranolol. Eur J Clin Pharmacol. 1983;25(4):437–441. doi: 10.1007/BF00542107. [DOI] [PubMed] [Google Scholar]
  2. Amelar R. D., Dubin L., Schoenfeld C. Sperm motility. Fertil Steril. 1980 Sep;34(3):197–215. doi: 10.1016/s0015-0282(16)44949-6. [DOI] [PubMed] [Google Scholar]
  3. Beach C. A., Bianchine J. R., Gerber N. The excretion of caffeine in the semen of men: pharmacokinetics and comparison of the concentrations in blood and semen. J Clin Pharmacol. 1984 Feb-Mar;24(2-3):120–126. doi: 10.1002/j.1552-4604.1984.tb02774.x. [DOI] [PubMed] [Google Scholar]
  4. Hong C. Y., Chaput de Saintonge D. M., Turner P. The inhibitory action of procaine, (+)-propranolol and (+/-)-propranolol on human sperm motility: antagonism by caffeine. Br J Clin Pharmacol. 1981 Nov;12(5):751–753. doi: 10.1111/j.1365-2125.1981.tb01301.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lizana J., Blad E. Immunonephelometry of specific proteins in human seminal plasma. Clin Chem. 1983 Apr;29(4):618–623. [PubMed] [Google Scholar]
  6. Peterson R. N., Freund M. Effects of (H + ), (Na + ), (K + ) and certain membrane-active drugs on glycolysis, motility, and ATP synthesis by human spermatozoa. Biol Reprod. 1973 Apr;8(3):350–357. doi: 10.1093/biolreprod/8.3.350. [DOI] [PubMed] [Google Scholar]
  7. Peterson R. N., Freund M. The inhibition of the motility of human spermatozoa by various pharmacologic agents. Biol Reprod. 1975 Dec;13(5):552–556. doi: 10.1095/biolreprod13.5.552. [DOI] [PubMed] [Google Scholar]
  8. RABOCH J., SKOCHOVA J. THE PH OF HUMAN EJACULATE. Fertil Steril. 1965 Mar-Apr;16:252–256. doi: 10.1016/s0015-0282(16)35533-9. [DOI] [PubMed] [Google Scholar]
  9. Rui H., Gerhardt P., Mevåg B., Thomassen Y., Purvis K. Seminal plasma characteristics during frequent ejaculation. Int J Androl. 1984 Apr;7(2):119–128. doi: 10.1111/j.1365-2605.1984.tb00767.x. [DOI] [PubMed] [Google Scholar]
  10. Schneider R. E., Bishop H., Yates R. A., Quarterman C. P., Kendall M. J. Effect of age on plasma propranolol levels. Br J Clin Pharmacol. 1980 Aug;10(2):169–171. doi: 10.1111/j.1365-2125.1980.tb01736.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Shand D. G., Nuckolls E. M., Oates J. A. Plasma propranolol levels in adults with observations in four children. Clin Pharmacol Ther. 1970 Jan-Feb;11(1):112–120. doi: 10.1002/cpt1970111112. [DOI] [PubMed] [Google Scholar]
  12. Swanson B. N., Leger R. M., Gordon W. P., Lynn R. K., Gerber N. Excretion of phenytoin into semen of rabbits and man. Comparison with plasma levels. Drug Metab Dispos. 1978 Jan-Feb;6(1):70–74. [PubMed] [Google Scholar]
  13. Takeguchi C. A., Honegger U. E., Holland W. W., Titus E. O. Evidence for subclasses of SH groups in (Na++K+)-ATPase. Life Sci. 1976 Sep 15;19(6):797–805. doi: 10.1016/0024-3205(76)90306-4. [DOI] [PubMed] [Google Scholar]
  14. Tulandi T., Plouffe L., Jr, McInnes R. A. Effect of saliva on sperm motility and activity. Fertil Steril. 1982 Dec;38(6):721–723. doi: 10.1016/s0015-0282(16)46700-2. [DOI] [PubMed] [Google Scholar]
  15. Zipper J., Bruzzone M. E., Angelo S., Muñoz V., Wheeler R. G. Effect of topically applied adrenergic blockers on fertility. Int J Fertil. 1982;27(4):242–245. [PubMed] [Google Scholar]
  16. Zipper J., Wheeler R. G., Potts D. M., Rivera M. Propranolol as a novel, effective spermicide: preliminary findings. Br Med J (Clin Res Ed) 1983 Oct 29;287(6401):1245–1246. doi: 10.1136/bmj.287.6401.1245. [DOI] [PMC free article] [PubMed] [Google Scholar]

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