Abstract
SBASE 5.0 is the fifth release of SBASE, a collection of annotated protein domain sequences that represent various structural, functional, ligand-binding and topogenic segments of proteins. SBASE was designed to facilitate the detection of functional homologies and can be searched with standard database-search programs. The present release contains over 79863 entries provided with standardized names and is cross-referenced to all major sequence databases and sequence pattern collections. The information is assigned to individual domains rather than to entire protein sequences, thus SBASE contains substantially more cross-references and links than do the protein sequence databases. The entries are clustered into >16 000 groups in order to facilitate the detection of distant similarities. SBASE 5.0 is freely available by anonymous 'ftp' file transfer from <ftp.icgeb.trieste.it >. Automated searching of SBASE with BLAST can be carried out with the WWW-server <http://www.icgeb.trieste.it/sbase/ >. and with the electronic mail server <sbase@icgeb.trieste.it >which now also provides a graphic representation of the homologies. A related WWW-server <http://www.abc.hu/blast.html > and e-mail server <domain@hubi.abc.hu > predicts SBASE domain homologies on the basis of SWISS-PROT searches.
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- Altschul S. F., Lipman D. J. Protein database searches for multiple alignments. Proc Natl Acad Sci U S A. 1990 Jul;87(14):5509–5513. doi: 10.1073/pnas.87.14.5509. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Attwood T. K., Beck M. E., Bleasby A. J., Degtyarenko K., Parry Smith D. J. Progress with the PRINTS protein fingerprint database. Nucleic Acids Res. 1996 Jan 1;24(1):182–188. doi: 10.1093/nar/24.1.182. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bairoch A., Apweiler R. The SWISS-PROT protein sequence data bank and its new supplement TREMBL. Nucleic Acids Res. 1996 Jan 1;24(1):21–25. doi: 10.1093/nar/24.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bairoch A., Bucher P., Hofmann K. The PROSITE database, its status in 1995. Nucleic Acids Res. 1996 Jan 1;24(1):189–196. doi: 10.1093/nar/24.1.189. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barker W. C., Hunt L. T., George D. G. Identifying domains in protein sequences. Protein Seq Data Anal. 1988;1(5):363–373. [PubMed] [Google Scholar]
- Baron M., Norman D. G., Campbell I. D. Protein modules. Trends Biochem Sci. 1991 Jan;16(1):13–17. doi: 10.1016/0968-0004(91)90009-k. [DOI] [PubMed] [Google Scholar]
- Benson D. A., Boguski M., Lipman D. J., Ostell J. GenBank. Nucleic Acids Res. 1996 Jan 1;24(1):1–5. doi: 10.1093/nar/24.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bernstein F. C., Koetzle T. F., Williams G. J., Meyer E. F., Jr, Brice M. D., Rodgers J. R., Kennard O., Shimanouchi T., Tasumi M. The Protein Data Bank: a computer-based archival file for macromolecular structures. J Mol Biol. 1977 May 25;112(3):535–542. doi: 10.1016/s0022-2836(77)80200-3. [DOI] [PubMed] [Google Scholar]
- Devereux J., Haeberli P., Smithies O. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387–395. doi: 10.1093/nar/12.1part1.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- George D. G., Barker W. C., Mewes H. W., Pfeiffer F., Tsugita A. The PIR-International Protein Sequence Database. Nucleic Acids Res. 1996 Jan 1;24(1):17–20. doi: 10.1093/nar/24.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hegyi H., Pongor S. Predicting potential domain homologies from FASTA search results. Comput Appl Biosci. 1993 Jun;9(3):371–372. doi: 10.1093/bioinformatics/9.3.371. [DOI] [PubMed] [Google Scholar]
- Lipman D. J., Pearson W. R. Rapid and sensitive protein similarity searches. Science. 1985 Mar 22;227(4693):1435–1441. doi: 10.1126/science.2983426. [DOI] [PubMed] [Google Scholar]
- Pearson P., Francomano C., Foster P., Bocchini C., Li P., McKusick V. The status of online Mendelian inheritance in man (OMIM) medio 1994. Nucleic Acids Res. 1994 Sep;22(17):3470–3473. doi: 10.1093/nar/22.17.3470. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pietrokovski S., Henikoff J. G., Henikoff S. The Blocks database--a system for protein classification. Nucleic Acids Res. 1996 Jan 1;24(1):197–200. doi: 10.1093/nar/24.1.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pongor S., Hátsági Z., Degtyarenko K., Fábián P., Skerl V., Hegyi H., Murvai J., Bevilacqua V. The SBASE protein domain library, release 3.0: a collection of annotated protein sequence segments. Nucleic Acids Res. 1994 Sep;22(17):3610–3615. [PMC free article] [PubMed] [Google Scholar]
- Pongor S., Skerl V., Cserzö M., Hátsági Z., Simon G., Bevilacqua V. The SBASE domain library: a collection of annotated protein segments. Protein Eng. 1993 Jun;6(4):391–395. doi: 10.1093/protein/6.4.391. [DOI] [PubMed] [Google Scholar]
- Roberts R. J., Macelis D. REBASE--restriction enzymes and methylases. Nucleic Acids Res. 1996 Jan 1;24(1):223–235. doi: 10.1093/nar/24.1.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rodriguez-Tomé P., Stoehr P. J., Cameron G. N., Flores T. P. The European Bioinformatics Institute (EBI) databases. Nucleic Acids Res. 1996 Jan 1;24(1):6–12. doi: 10.1093/nar/24.1.6. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sonnhammer E. L., Durbin R. A workbench for large-scale sequence homology analysis. Comput Appl Biosci. 1994 Jun;10(3):301–307. doi: 10.1093/bioinformatics/10.3.301. [DOI] [PubMed] [Google Scholar]
- Sonnhammer E. L., Kahn D. Modular arrangement of proteins as inferred from analysis of homology. Protein Sci. 1994 Mar;3(3):482–492. doi: 10.1002/pro.5560030314. [DOI] [PMC free article] [PubMed] [Google Scholar]