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. 1985;19(Suppl 2):113S–118S. doi: 10.1111/j.1365-2125.1985.tb02751.x

Investigation of drug absorption from the gastrointestinal tract of man

III. Metoprolol in the colon

J Godbillon, D Evard, N Vidon, M Duval, J P Schoeller, J J Bernier, J Hirtz
PMCID: PMC1463759  PMID: 4005112

Abstract

1 The colonic absorption of metoprolol was indirectly evaluated by measuring drug appearance in plasma following intravenous, jejunal or colonic infusion in six healthy volunteers. Plasma concentrations of α-hydroxymetoprolol and urinary excretion of the main metabolites were also measured.

2 Plasma profiles of metoprolol after colonic and jejunal perfusion were similar, and the relative bioavailabilities of the drug from these two regions of the gut were not significantly different.

3 The concentrations of α-hydroxymetoprolol, the major metabolite in plasma, were similar after jejunal and colonic perfusion, but higher than those observed after intravenous administration.

4 The percentage of the dose recovered in urine over 24 h as two metabolites was not significantly influenced by the route of administration.

Keywords: metoprolol, drug absorption, colon

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Selected References

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