Abstract
Four different dose forms of mebendazole were administered to human volunteers, and urine was collected and assayed for mebendazole and unconjugated metabolites of mebendazole. Oral administration of mebendazole as an oily suspension slightly enhances the bioavailability of the drug, however mebendazole is not absorbed following rectal administration. The major urinary metabolite of mebendazole in humans is 2-amino-5(6)[alpha-hydroxybenzyl]benzimidazole (IV), not 2-amino-5(6) benzoylbenzimidazole (II), as previously reported.
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- Brugmans J. P., Thienpont D. C., van Wijngaarden I., Vanparijs O. F., Schuermans V. L., Lauwers H. L. Mebendazole in enterobiasis. Radiochemical and pilot clinical study in 1,278 subjects. JAMA. 1971 Jul 19;217(3):313–316. [PubMed] [Google Scholar]
- Bryceson A. D., Woestenborghs R., Michiels M., van den Bossche H. Bioavailability and tolerability of mebendazole in patients with inoperable hydatid disease. Trans R Soc Trop Med Hyg. 1982;76(4):563–564. doi: 10.1016/0035-9203(82)90163-8. [DOI] [PubMed] [Google Scholar]
- Dawson M., Braithwaite P. A., Roberts M. S., Watson T. R. The pharmacokinetics and bioavailability of a tracer dose of [3H]-mebendazole in man. Br J Clin Pharmacol. 1985 Jan;19(1):79–86. doi: 10.1111/j.1365-2125.1985.tb02616.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dawson M., Watson T. R. 4-Amino-3-(3'-methoxycarbonyl-2'-thioureido)benzophenone, a prodrug of mebendazole. Eur J Drug Metab Pharmacokinet. 1983 Oct-Dec;8(4):329–334. doi: 10.1007/BF03188765. [DOI] [PubMed] [Google Scholar]
- Münst G. J., Karlaganis G., Bircher J. Plasma concentrations of mebendazole during treatment of echinococcosis: preliminary results. Eur J Clin Pharmacol. 1980 May;17(5):375–378. doi: 10.1007/BF00558451. [DOI] [PubMed] [Google Scholar]
- Witassek F., Burkhardt B., Eckert J., Bircher J. Chemotherapy of alveolar echinococcosis. Comparison of plasma mebendazole concentrations in animals and man. Eur J Clin Pharmacol. 1981;20(6):427–433. doi: 10.1007/BF00542095. [DOI] [PubMed] [Google Scholar]