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. 1985 Apr;19(4):453–457. doi: 10.1111/j.1365-2125.1985.tb02670.x

Increased platelet membrane [3H]-LSD binding in patients on chronic neuroleptic treatment.

M Schächter, D P Geaney, D G Grahame-Smith, P J Cowen, J M Elliott
PMCID: PMC1463802  PMID: 2859873

Abstract

Using a [3H]-lysergic acid diethylamide [( 3H]-LSD) binding technique, platelet 5-hydroxytryptamine (5-HT) receptor number and affinity were compared in schizophrenics treated with depot thioxanthenes and phenothiazines and controls. There was an approximately 30% increase in platelet receptor number (Bmax) in the patient group. There was a decrease in affinity (increase in Kd) of about 30% in the patient group. This was probably due to the persistence of the neuroleptic in the platelet membrane preparation. There was a weak positive correlation between receptor number and total neuroleptic dosage. The increased number of 5-HT receptors is consistent with the previously reported enhancement of 5-HT-induced platelet aggregation in patients treated with long-term phenothiazines and thioxanthenes. Our findings are compatible with 5-HT up-regulation in human platelets produced by depot neuroleptic therapy. It is not known whether parallel changes may be occurring in brain 5-HT receptors.

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Selected References

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