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. 1985 Apr;19(4):417–421. doi: 10.1111/j.1365-2125.1985.tb02664.x

The effects of propranolol and digoxin on the acute vascular responses to frusemide in normal man.

G D Johnston, P C O'Connor, D P Nicholls, W J Leahey, M B Finch
PMCID: PMC1463813  PMID: 3888240

Abstract

To examine the importance of acute frusemide-induced renin release in the production of the acute peripheral venous and arterial responses to frusemide in man, the effects of two drugs, previously described as inhibitors of acute frusemide-induced renin release, propranolol and digoxin, were examined. Propranolol abolished the acute increases in venous capacitance and blood pressure and attenuated the increases in forearm vascular resistance produced by frusemide. The acute increases in plasma renin activity and plasma aldosterone concentrations were also abolished. Pre-treatment with digoxin had no effect on the acute peripheral vascular responses to frusemide and failed to inhibit the acute increases in plasma renin activity and plasma aldosterone produced by frusemide. The study provides further evidence of a relationship between acute frusemide-induced renin release and the acute peripheral vascular effects of frusemide in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bravo E. L., Tarazi R. C., Dustan H. P. On the mechanism of suppressed plasma-renin activity during beta-adrenergic blockade with propranolol. J Lab Clin Med. 1974 Jan;83(1):119–128. [PubMed] [Google Scholar]
  2. Covit A. B., Schaer G. L., Sealey J. E., Laragh J. H., Cody R. J. Suppression of the renin-angiotensin system by intravenous digoxin in chronic congestive heart failure. Am J Med. 1983 Sep;75(3):445–447. doi: 10.1016/0002-9343(83)90346-7. [DOI] [PubMed] [Google Scholar]
  3. Dikshit K., Vyden J. K., Forrester J. S., Chatterjee K., Prakash R., Swan H. J. Renal and extrarenal hemodynamic effects of furosemide in congestive heart failure after acute myocardial infarction. N Engl J Med. 1973 May 24;288(21):1087–1090. doi: 10.1056/NEJM197305242882102. [DOI] [PubMed] [Google Scholar]
  4. Ferrari M. Effects of digoxin and digoxin plus furosemide on plasma renin activity of hypertensive patients. Circ Res. 1979 Feb;44(2):295–295. doi: 10.1161/01.res.44.2.295. [DOI] [PubMed] [Google Scholar]
  5. Gerber J. G., Olson R. D., Nies A. S. Interrelationship between prostaglandins and renin release. Kidney Int. 1981 Jun;19(6):816–821. doi: 10.1038/ki.1981.85. [DOI] [PubMed] [Google Scholar]
  6. Gimbrone M. A., Jr, Alexander R. W. Angiotensin II stimulation of prostaglandin production in cultured human vascular endothelium. Science. 1975 Jul 18;189(4198):219–220. doi: 10.1126/science.1138377. [DOI] [PubMed] [Google Scholar]
  7. Haber E., Koerner T., Page L. B., Kliman B., Purnode A. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab. 1969 Oct;29(10):1349–1355. doi: 10.1210/jcem-29-10-1349. [DOI] [PubMed] [Google Scholar]
  8. Johnston G. D., Hiatt W. R., Nies A. S., Payne N. A., Murphy R. C., Gerber J. G. Factors modifying the early nondiuretic vascular effects of furosemide in man. The possible role of renal prostaglandins. Circ Res. 1983 Nov;53(5):630–635. doi: 10.1161/01.res.53.5.630. [DOI] [PubMed] [Google Scholar]
  9. Johnston G. D., Nicholls D. P., Leahey W. J., Finch M. B. The effects of captopril on the acute vascular responses to frusemide in man. Clin Sci (Lond) 1983 Oct;65(4):359–363. doi: 10.1042/cs0650359. [DOI] [PubMed] [Google Scholar]
  10. Liang C. S., Gavras H., Hood W. B., Jr Renin-angiotensin system inhibition in conscious sodium-depleted dogs. Effects on systemic and coronary hemodynamics. J Clin Invest. 1978 Apr;61(4):874–883. doi: 10.1172/JCI109013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Moncada S., Higgs E. A., Vane J. R. Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation. Lancet. 1977 Jan 1;1(8001):18–20. doi: 10.1016/s0140-6736(77)91655-5. [DOI] [PubMed] [Google Scholar]
  12. Montanaro D., Antonello A., Baggio B., Finotti P., Melacini P., Ferrari M. Effects of digoxin on plasma renin activity in hypertensive patients. Int J Clin Pharmacol Ther Toxicol. 1980 Jul;18(7):322–323. [PubMed] [Google Scholar]
  13. Patrono C., Pugliese F., Ciabattoni G., Patrignani P., Maseri A., Chierchia S., Peskar B. A., Cinotti G. A., Simonetti B. M., Pierucci A. Evidence for a direct stimulatory effect of prostacyclin on renin release in man. J Clin Invest. 1982 Jan;69(1):231–239. doi: 10.1172/JCI110435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Steer M. L., MacIntyre D. E., Levine L., Salzman E. W. Is prostacyclin a physiologically important circulating anti-platelet agent? Nature. 1980 Jan 10;283(5743):194–195. doi: 10.1038/283194a0. [DOI] [PubMed] [Google Scholar]
  15. WHITNEY R. J. The measurement of volume changes in human limbs. J Physiol. 1953 Jul;121(1):1–27. doi: 10.1113/jphysiol.1953.sp004926. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Wright B. M., Dore C. F. A random-zero sphygmomanometer. Lancet. 1970 Feb 14;1(7642):337–338. doi: 10.1016/s0140-6736(70)90709-9. [DOI] [PubMed] [Google Scholar]

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