Abstract
Triazolam 0.5 mg was administered to 11 dialysis patients and 11 age, weight and sex matched controls. Peak plasma concentrations (Cmax) were higher in control subjects, but there were no other differences between the groups. When dialysis patients took triazolam with 3600 mg aluminum hydroxide suspension, Cmax and AUC were increased into the range observed in control subjects. It appears that triazolam can be used at normal doses in patients with renal dysfunction, without regard to interaction with aluminum hydroxide gel, or to alterations in elimination.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abernethy D. R., Greenblatt D. J., Divoll M., Moschitto L. J., Harmatz J. S., Shader R. I. Interaction of cimetidine with the triazolobenzodiazepines alprazolam and triazolam. Psychopharmacology (Berl) 1983;80(3):275–278. doi: 10.1007/BF00436169. [DOI] [PubMed] [Google Scholar]
- Eberts F. S., Jr, Philopoulos Y., Reineke L. M., Vliek R. W. Triazolam disposition. Clin Pharmacol Ther. 1981 Jan;29(1):81–93. doi: 10.1038/clpt.1981.14. [DOI] [PubMed] [Google Scholar]
- Elwood R. J., Hildebrand P. J., Dundee J. W., Collier P. S. Ranitidine influences the uptake of oral midazolam. Br J Clin Pharmacol. 1983 Jun;15(6):743–745. doi: 10.1111/j.1365-2125.1983.tb01559.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greenblatt D. J., Allen M. D., MacLaughlin D. S., Harmatz J. S., Shader R. I. Diazepam absorption: effect of antacids and food. Clin Pharmacol Ther. 1978 Nov;24(5):600–609. doi: 10.1002/cpt1978245600. [DOI] [PubMed] [Google Scholar]
- Greenblatt D. J., Divoll M., Moschitto L. J., Shader R. I. Electron-capture gas chromatographic analysis of the triazolobenzodiazepines alprazolam and triazolam. J Chromatogr. 1981 Sep 11;225(1):202–207. doi: 10.1016/s0378-4347(00)80261-3. [DOI] [PubMed] [Google Scholar]
- Greenblatt D. J., Shader R. I., Harmatz J. S., Franke K., Koch-Weser J. Influence of magnesium and aluminum hydroxide mixture on chlordiazepoxide absorption. Clin Pharmacol Ther. 1976 Feb;19(2):234–239. doi: 10.1002/cpt1976192234. [DOI] [PubMed] [Google Scholar]
- Konishi M., Hirai K., Mori Y. Kinetics and mechanism of the equilibrium reaction of triazolam in aqueous solution. J Pharm Sci. 1982 Dec;71(12):1328–1334. doi: 10.1002/jps.2600711206. [DOI] [PubMed] [Google Scholar]
- Kroboth P. D., Smith R. B., Sorkin M. I., Silver M. R., Rault R., Garry M., Juhl R. P. Triazolam protein binding and correlation with alpha-1 acid glycoprotein concentration. Clin Pharmacol Ther. 1984 Sep;36(3):379–383. doi: 10.1038/clpt.1984.191. [DOI] [PubMed] [Google Scholar]