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. 2005 May 1;564(Pt 3):953. doi: 10.1113/jphysiol.2005.564001

Errata

PMCID: PMC1464459

The authors of Rivera et al. (2005) would like to publish the following clarification: in our review, we emphasized the fact that using Cs+ as an internal cation in whole-cell recordings results in a profound dysfunction of the neuronal K+–Cl cotransporter, KCC2. This is because Cs+ is a very poor substrate of this ion transporter, with a maximum transport rate (Vmax) for Cs+ that is < 20% of the value for K+ (Williams & Payne, 2004). On page 29, we stated that ‘Unfortunately, the kinetic data in the only published model of neuronal K+–Cl cotransport in neurones (Staley & Proctor, 1999) were obtained using Cs+ in whole-cell experiments – and hence, in the absence of functional KCC2!’ Since the publication of our review, it has been brought to our attention that both K+ and Cs+ were used by the authors, with essentially similar results. This is true and, if anything, it strengthens our concerns about the validity of the above modelling study which yielded a value of Vmax for Cs+ that is higher than for K+ (about 7 mmol l−1 s−1 for Cs+ and about 5–6 mmol l−1 s−1 for K+).

The authors of Zhang & Paterson, (2005) would like to correct an error on page 858. In line 7 of the first paragraph, a value of 361 ± 83 ms is given for the control. This value should have read 661 ± 83 ms. In addition, in the title ‘guniea-pig’ should be ‘guinea-pig’.

The authors of Capote et al. (2005) would like to correct the affiliation of Carlo Caputo; the affiliation should be the Instituto Venezolano de Investigaciones Cientificas IVIC.

References

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