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. 1999 Mar;11(3):301–308. doi: 10.1105/tpc.11.3.301

Tobacco Mosaic Virus: Pioneering Research for a Century

A N Creager, K Scholthof, V Citovsky, H B Scholthof
PMCID: PMC1464663  PMID: 10072391

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERER F. A., UHLIG H., WEBER E., SCHRAMM G. Primary structure of the protein of tobacco mosaic virus. Nature. 1960 Jun 18;186:922–925. doi: 10.1038/186922a0. [DOI] [PubMed] [Google Scholar]
  2. Abel P. P., Nelson R. S., De B., Hoffmann N., Rogers S. G., Fraley R. T., Beachy R. N. Delay of disease development in transgenic plants that express the tobacco mosaic virus coat protein gene. Science. 1986 May 9;232(4751):738–743. doi: 10.1126/science.3457472. [DOI] [PubMed] [Google Scholar]
  3. Atabekov J. G., Taliansky M. E. Expression of a plant virus-coded transport function by different viral genomes. Adv Virus Res. 1990;38:201–248. doi: 10.1016/s0065-3527(08)60863-5. [DOI] [PubMed] [Google Scholar]
  4. Atkinson P. H., Matthews R. E. On the origin of dark green tissue in tobacco leaves infected with tobacco mosaic virus. Virology. 1970 Feb;40(2):344–356. doi: 10.1016/0042-6822(70)90411-3. [DOI] [PubMed] [Google Scholar]
  5. Beachy R. N., Zaitlin M., Bruening G., Israel H. W. A genetic map for the cowpea strain on TMV. Virology. 1976 Sep;73(2):498–507. doi: 10.1016/0042-6822(76)90411-6. [DOI] [PubMed] [Google Scholar]
  6. Bendahmane M., Fitchen J. H., Zhang G., Beachy R. N. Studies of coat protein-mediated resistance to tobacco mosaic tobamovirus: correlation between assembly of mutant coat proteins and resistance. J Virol. 1997 Oct;71(10):7942–7950. doi: 10.1128/jvi.71.10.7942-7950.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bos L. The embryonic beginning of virology: unbiased thinking and dogmatic stagnation. Arch Virol. 1995;140(3):613–619. doi: 10.1007/BF01718437. [DOI] [PubMed] [Google Scholar]
  8. Butler P. J. The current picture of the structure and assembly of tobacco mosaic virus. J Gen Virol. 1984 Feb;65(Pt 2):253–279. doi: 10.1099/0022-1317-65-2-253. [DOI] [PubMed] [Google Scholar]
  9. CASPAR D. L. The structural stability of tocacco mosaic virus. Trans N Y Acad Sci. 1960 May;22:519–521. doi: 10.1111/j.2164-0947.1960.tb00721.x. [DOI] [PubMed] [Google Scholar]
  10. CRICK F. H., WATSON J. D. Structure of small viruses. Nature. 1956 Mar 10;177(4506):473–475. doi: 10.1038/177473a0. [DOI] [PubMed] [Google Scholar]
  11. Citovsky V., Knorr D., Schuster G., Zambryski P. The P30 movement protein of tobacco mosaic virus is a single-strand nucleic acid binding protein. Cell. 1990 Feb 23;60(4):637–647. doi: 10.1016/0092-8674(90)90667-4. [DOI] [PubMed] [Google Scholar]
  12. Citovsky V., McLean B. G., Zupan J. R., Zambryski P. Phosphorylation of tobacco mosaic virus cell-to-cell movement protein by a developmentally regulated plant cell wall-associated protein kinase. Genes Dev. 1993 May;7(5):904–910. doi: 10.1101/gad.7.5.904. [DOI] [PubMed] [Google Scholar]
  13. Clark S. E. Organ Formation at the Vegetative Shoot Meristem. Plant Cell. 1997 Jul;9(7):1067–1076. doi: 10.1105/tpc.9.7.1067. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Clark S. E., Williams R. W., Meyerowitz E. M. The CLAVATA1 gene encodes a putative receptor kinase that controls shoot and floral meristem size in Arabidopsis. Cell. 1997 May 16;89(4):575–585. doi: 10.1016/s0092-8674(00)80239-1. [DOI] [PubMed] [Google Scholar]
  15. Dawson W. O., Beck D. L., Knorr D. A., Grantham G. L. cDNA cloning of the complete genome of tobacco mosaic virus and production of infectious transcripts. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1832–1836. doi: 10.1073/pnas.83.6.1832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Deom C. M., Oliver M. J., Beachy R. N. The 30-kilodalton gene product of tobacco mosaic virus potentiates virus movement. Science. 1987 Jul 24;237(4813):389–394. doi: 10.1126/science.237.4813.389. [DOI] [PubMed] [Google Scholar]
  17. FRAENKEL-CONRAT H., SINGER B. Virus reconstitution. II. Combination of protein and nucleic acid from different strains. Biochim Biophys Acta. 1957 Jun;24(3):540–548. doi: 10.1016/0006-3002(57)90244-5. [DOI] [PubMed] [Google Scholar]
  18. FRANKLIN R. E. Structure of tobacco mosaic virus. Nature. 1955 Feb 26;175(4452):379–381. doi: 10.1038/175379a0. [DOI] [PubMed] [Google Scholar]
  19. Fraenkel-Conrat H., Williams R. C. RECONSTITUTION OF ACTIVE TOBACCO MOSAIC VIRUS FROM ITS INACTIVE PROTEIN AND NUCLEIC ACID COMPONENTS. Proc Natl Acad Sci U S A. 1955 Oct 15;41(10):690–698. doi: 10.1073/pnas.41.10.690. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Fraile A., Escriu F., Aranda M. A., Malpica J. M., Gibbs A. J., García-Arenal F. A century of tobamovirus evolution in an Australian population of Nicotiana glauca. J Virol. 1997 Nov;71(11):8316–8320. doi: 10.1128/jvi.71.11.8316-8320.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. GIERER A., MUNDRY K. W. Production of mutants of tobacco mosaic virus by chemical alteration of its ribonucleic acid in vitro. Nature. 1958 Nov 22;182(4647):1457–1458. doi: 10.1038/1821457a0. [DOI] [PubMed] [Google Scholar]
  22. GIERER A., SCHRAMM G. Infectivity of ribonucleic acid from tobacco mosaic virus. Nature. 1956 Apr 14;177(4511):702–703. doi: 10.1038/177702a0. [DOI] [PubMed] [Google Scholar]
  23. Gafny R., Lapidot M., Berna A., Holt C. A., Deom C. M., Beachy R. N. Effects of terminal deletion mutations on function of the movement protein of tobacco mosaic virus. Virology. 1992 Apr;187(2):499–507. doi: 10.1016/0042-6822(92)90452-u. [DOI] [PubMed] [Google Scholar]
  24. Gallie D. R., Sleat D. E., Watts J. W., Turner P. C., Wilson T. M. The 5'-leader sequence of tobacco mosaic virus RNA enhances the expression of foreign gene transcripts in vitro and in vivo. Nucleic Acids Res. 1987 Apr 24;15(8):3257–3273. doi: 10.1093/nar/15.8.3257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Goelet P., Lomonossoff G. P., Butler P. J., Akam M. E., Gait M. J., Karn J. Nucleotide sequence of tobacco mosaic virus RNA. Proc Natl Acad Sci U S A. 1982 Oct;79(19):5818–5822. doi: 10.1073/pnas.79.19.5818. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Heinlein M., Epel B. L., Padgett H. S., Beachy R. N. Interaction of tobamovirus movement proteins with the plant cytoskeleton. Science. 1995 Dec 22;270(5244):1983–1985. doi: 10.1126/science.270.5244.1983. [DOI] [PubMed] [Google Scholar]
  27. Hua J., Sakai H., Nourizadeh S., Chen Q. G., Bleecker A. B., Ecker J. R., Meyerowitz E. M. EIN4 and ERS2 are members of the putative ethylene receptor gene family in Arabidopsis. Plant Cell. 1998 Aug;10(8):1321–1332. doi: 10.1105/tpc.10.8.1321. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Hunter T. R., Hunt T., Knowland J., Zimmern D. Messenger RNA for the coat protein of tobacco mosaic virus. Nature. 1976 Apr 29;260(5554):759–764. doi: 10.1038/260759a0. [DOI] [PubMed] [Google Scholar]
  29. Jackson A. O., Zaitlin M., Siegel A., Francki R. I. Replication of tobacco mosaic virus. 3. Viral RNA metabolism in separated leaf cells. Virology. 1972 Jun;48(3):655–665. doi: 10.1016/0042-6822(72)90150-x. [DOI] [PubMed] [Google Scholar]
  30. Kay L. E. A book of life? How the genome became an information system and DNA a language. Perspect Biol Med. 1998 Summer;41(4):504–528. doi: 10.1353/pbm.1998.0038. [DOI] [PubMed] [Google Scholar]
  31. LAUFFER M. A., ANSEVIN A. T., CARTWRIGHT T. E., BRINTON C. C., Jr Polymerization-depolymerization of tobacco mosaic virus protein. Nature. 1958 May 10;181(4619):1338–1339. doi: 10.1038/1811338b0. [DOI] [PubMed] [Google Scholar]
  32. Lartey R. T., Ghoshroy S., Citovsky V. Identification of an Arabidopsis thaliana mutation (vsm1) that restricts systemic movement of tobamoviruses. Mol Plant Microbe Interact. 1998 Jul;11(7):706–709. doi: 10.1094/MPMI.1998.11.7.706. [DOI] [PubMed] [Google Scholar]
  33. Lease K., Ingham E., Walker J. C. Challenges in understanding RLK function. Curr Opin Plant Biol. 1998 Oct;1(5):388–392. doi: 10.1016/s1369-5266(98)80261-6. [DOI] [PubMed] [Google Scholar]
  34. McLean B. G., Zupan J., Zambryski P. C. Tobacco mosaic virus movement protein associates with the cytoskeleton in tobacco cells. Plant Cell. 1995 Dec;7(12):2101–2114. doi: 10.1105/tpc.7.12.2101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Meshi T., Ishikawa M., Motoyoshi F., Semba K., Okada Y. In vitro transcription of infectious RNAs from full-length cDNAs of tobacco mosaic virus. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5043–5047. doi: 10.1073/pnas.83.14.5043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Namba K., Pattanayek R., Stubbs G. Visualization of protein-nucleic acid interactions in a virus. Refined structure of intact tobacco mosaic virus at 2.9 A resolution by X-ray fiber diffraction. J Mol Biol. 1989 Jul 20;208(2):307–325. doi: 10.1016/0022-2836(89)90391-4. [DOI] [PubMed] [Google Scholar]
  37. Ohno T., Takamatsu N., Meshi T., Okada Y., Nishiguchi M., Kiho Y. Single amino acid substitution in 30K protein of TMV defective in virus transport function. Virology. 1983 Nov;131(1):255–258. doi: 10.1016/0042-6822(83)90551-2. [DOI] [PubMed] [Google Scholar]
  38. Pelham H. R. Leaky UAG termination codon in tobacco mosaic virus RNA. Nature. 1978 Mar 30;272(5652):469–471. doi: 10.1038/272469a0. [DOI] [PubMed] [Google Scholar]
  39. Ridley A. J., Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992 Aug 7;70(3):389–399. doi: 10.1016/0092-8674(92)90163-7. [DOI] [PubMed] [Google Scholar]
  40. Solano R., Ecker J. R. Ethylene gas: perception, signaling and response. Curr Opin Plant Biol. 1998 Oct;1(5):393–398. doi: 10.1016/s1369-5266(98)80262-8. [DOI] [PubMed] [Google Scholar]
  41. Stanley W. M. ISOLATION OF A CRYSTALLINE PROTEIN POSSESSING THE PROPERTIES OF TOBACCO-MOSAIC VIRUS. Science. 1935 Jun 28;81(2113):644–645. doi: 10.1126/science.81.2113.644. [DOI] [PubMed] [Google Scholar]
  42. Stone J. M., Collinge M. A., Smith R. D., Horn M. A., Walker J. C. Interaction of a protein phosphatase with an Arabidopsis serine-threonine receptor kinase. Science. 1994 Nov 4;266(5186):793–795. doi: 10.1126/science.7973632. [DOI] [PubMed] [Google Scholar]
  43. Stone JM, Trotochaud AE, Walker JC, Clark SE. Control of meristem development by CLAVATA1 receptor kinase and kinase-associated protein phosphatase interactions . Plant Physiol. 1998 Aug;117(4):1217–1225. doi: 10.1104/pp.117.4.1217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Tari A. M., Hung M. C., Li K., Lopez-Berestein G. Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells. Oncogene. 1999 Feb 11;18(6):1325–1332. doi: 10.1038/sj.onc.1202422. [DOI] [PubMed] [Google Scholar]
  45. Trotochaud A. E., Hao T., Wu G., Yang Z., Clark S. E. The CLAVATA1 receptor-like kinase requires CLAVATA3 for its assembly into a signaling complex that includes KAPP and a Rho-related protein. Plant Cell. 1999 Mar;11(3):393–406. doi: 10.1105/tpc.11.3.393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Tsugita A., Gish D. T., Young J., Fraenkel-Conrat H., Knight C. A., Stanley W. M. THE COMPLETE AMINO ACID SEQUENCE OF THE PROTEIN OF TOBACCO MOSAIC VIRUS. Proc Natl Acad Sci U S A. 1960 Nov;46(11):1463–1469. doi: 10.1073/pnas.46.11.1463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. WATSON J. D. The structure of tobacco mosaic virus. I. X-ray evidence of a helical arrangement of sub-units around the longitudinal axis. Biochim Biophys Acta. 1954 Jan;13(1):10–19. doi: 10.1016/0006-3002(54)90265-6. [DOI] [PubMed] [Google Scholar]
  48. Waigmann E., Lucas W. J., Citovsky V., Zambryski P. Direct functional assay for tobacco mosaic virus cell-to-cell movement protein and identification of a domain involved in increasing plasmodesmal permeability. Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1433–1437. doi: 10.1073/pnas.91.4.1433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Whitham S., McCormick S., Baker B. The N gene of tobacco confers resistance to tobacco mosaic virus in transgenic tomato. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8776–8781. doi: 10.1073/pnas.93.16.8776. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Williams R. W., Wilson J. M., Meyerowitz E. M. A possible role for kinase-associated protein phosphatase in the Arabidopsis CLAVATA1 signaling pathway. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10467–10472. doi: 10.1073/pnas.94.19.10467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Wolf S., Deom C. M., Beachy R. N., Lucas W. J. Movement protein of tobacco mosaic virus modifies plasmodesmatal size exclusion limit. Science. 1989 Oct 20;246(4928):377–379. doi: 10.1126/science.246.4928.377. [DOI] [PubMed] [Google Scholar]
  52. Wu X., Shaw J. G. Evidence that a viral replicase protein is involved in the disassembly of tobacco mosaic virus particles in vivo. Virology. 1997 Dec 22;239(2):426–434. doi: 10.1006/viro.1997.8870. [DOI] [PubMed] [Google Scholar]
  53. Wu X., Shaw J. Bidirectional uncoating of the genomic RNA of a helical virus. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2981–2984. doi: 10.1073/pnas.93.7.2981. [DOI] [PMC free article] [PubMed] [Google Scholar]

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