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Scheme for the generation of the ligation substrate. The 17-nt 5′ ligation substrate was generated using biotinylated 8–17 DNAzyme. This was hybridized together with the 3′ substrate fragment and strands a, b, and c in the presence of 1.5 mM HEPES (pH 7.5) to generate the ligation-competent hairpin ribozyme.
