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. 1997 Jun 15;25(12):2543–2545. doi: 10.1093/nar/25.12.2543

Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments.

C Barlow 1, M Schroeder 1, J Lekstrom-Himes 1, H Kylefjord 1, C X Deng 1, A Wynshaw-Boris 1, B M Spiegelman 1, K G Xanthopoulos 1
PMCID: PMC146759  PMID: 9171115

Abstract

Functional analysis of mammalian genes relies, in part, on targeted mutations generated by homologous recombination in mice. We have developed a strategy for adipose-specific inactivation of loxP-floxed gene segments. Transgenic mice have been established that express Cre recombinase under the control of the adipose-specific aP2 enhancer/promoter. Crossing of the aP2/ Cre mice with any loxP-floxed gene will facilitate its functional analysis in adipose tissue.

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Selected References

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