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. 1997 Apr;190(Pt 3):321–326. doi: 10.1046/j.1469-7580.1997.19030321.x

Catecholaminergic innervation of interscapular brown adipose tissue in the naked mole-rat (Heterocephalus glaber)

T JOSEPH M DALY 1 , LAURA A WILLIAMS 1 , ROCHELLE BUFFENSTEIN 2
PMCID: PMC1467613  PMID: 9147219

Abstract

The thermogenic potential of the interscapular brown fat pad in the naked mole-rat Heterocephalus glaber, that exhibits poikilothermic thermal responses to changing temperatures is reported. Histological and ultrastructural study of the brown fat pad showed that it consists of layers of skeletal muscle interposed between the layers of brown adipose tissue with both unilocular and multilocular adipocytes. Large numbers of mitochondria were present between and around the lipid droplets of these cells. Glyoxylic acid condensation, used to demonstrate catecholaminergic nerves, was evident in low concentrations in the connective tissue between the brown adipocytes. A 3-dimensional computer-aided reconstruction of the fat pad showed the extent and ramification of nerves and blood vessels between the adipocytes. These findings show that although the naked mole-rat is regarded as an endothermic poikilotherm, it possesses anatomical features usually found in homeothermic mammals, which are essential for thermogenesis.

Keywords: Thermogenesis, sympathetic innervation, brown adipose tissue, naked mole-rat

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Selected References

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  1. Carneheim C., Nedergaard J., Cannon B. Beta-adrenergic stimulation of lipoprotein lipase in rat brown adipose tissue during acclimation to cold. Am J Physiol. 1984 Apr;246(4 Pt 1):E327–E333. doi: 10.1152/ajpendo.1984.246.4.E327. [DOI] [PubMed] [Google Scholar]
  2. Cottle M. K., Cottle W. H. Adrenergic fibers in brown fat of cold-acclimated rats. J Histochem Cytochem. 1970 Feb;18(2):116–119. doi: 10.1177/18.2.116. [DOI] [PubMed] [Google Scholar]
  3. Cottle M. K., Cottle W. H., Pérusse F., Bukowiecki L. J. An improved glyoxylic acid technique for the histochemical localization of catecholamines in brown adipose tissue. Histochem J. 1985 Dec;17(12):1279–1288. doi: 10.1007/BF01002525. [DOI] [PubMed] [Google Scholar]
  4. Cunningham S., Leslie P., Hopwood D., Illingworth P., Jung R. T., Nicholls D. G., Peden N., Rafael J., Rial E. The characterization and energetic potential of brown adipose tissue in man. Clin Sci (Lond) 1985 Sep;69(3):343–348. doi: 10.1042/cs0690343. [DOI] [PubMed] [Google Scholar]
  5. Lever J. D., Jung R. T., Nnodim J. O., Leslie P. J., Symons D. Demonstration of a catecholaminergic innervation in human perirenal brown adipose tissue at various ages in the adult. Anat Rec. 1986 Jul;215(3):251-5, 227-9. doi: 10.1002/ar.1092150307. [DOI] [PubMed] [Google Scholar]
  6. Norman D., Mukherjee S., Symons D., Jung R. T., Lever J. D. Neuropeptides in interscapular and perirenal brown adipose tissue in the rat: a plurality of innervation. J Neurocytol. 1988 Jun;17(3):305–311. doi: 10.1007/BF01187853. [DOI] [PubMed] [Google Scholar]
  7. SMITH R. E. THERMOREGULATORY AND ADAPTIVE BEHAVIOR OF BROWN ADIPOSE TISSUE. Science. 1964 Dec 25;146(3652):1686–1689. doi: 10.1126/science.146.3652.1686. [DOI] [PubMed] [Google Scholar]
  8. Torre J. C., Surgeon J. W. A methodological approach to rapid and sensitive monoamine histofluorescence using a modified glyoxylic acid technique: the SPG method. Histochemistry. 1976 Oct 22;49(2):81–93. doi: 10.1007/BF00495672. [DOI] [PubMed] [Google Scholar]

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