Skip to main content
PMC home page
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1968 Dec;5(4):292–297. doi: 10.1136/jmg.5.4.292

Hereditary non-spherocytic haemolytic anaemia with post-splenectomy inclusion bodies and pigmenturia caused by an unstable haemoglobin Santa Ana-beta-88 (F4) leucine--proline.

R W Opfell, P A Lorkin, H Lehmann
PMCID: PMC1468682  PMID: 5713642

Full text

PDF

Images in this article

294Fig. 1.
on p.294
295Fig. 2.
on p.295

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beale D. A partial amino acid sequence for sheep haemoblogin A. Biochem J. 1967 Apr;103(1):129–140. doi: 10.1042/bj1030129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bradley T. B., Jr, Wohl R. C., Rieder R. F. Hemoglobin Gun Hill: deletion of five amino acid residues and impaired heme-globin binding. Science. 1967 Sep 29;157(3796):1581–1583. doi: 10.1126/science.157.3796.1581. [DOI] [PubMed] [Google Scholar]
  3. CRADOCK-WATSON J. E., FENTON J. C., LEHMANN H. Tris buffer for the demonstration of haemoglobin A2 by paper electrophoresis. J Clin Pathol. 1959 Jul;12:372–373. doi: 10.1136/jcp.12.4.372. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Carrell R. W., Lehmann H., Hutchison H. E. Haemoglobin Köln (beta-98 valine--methionine): an unstable protein causing inclusion-body anaemia. Nature. 1966 May 28;210(5039):915–916. doi: 10.1038/210915a0. [DOI] [PubMed] [Google Scholar]
  5. Carrell R. W., Lehmann H., Lorkin P. A., Raik E., Hunter E. Haemoglobin sydney: Beta-67 (E11) valine modified to alanine: an emerging pattern of unstable haemoglobins. Nature. 1967 Aug 5;215(5101):626–628. doi: 10.1038/215626a0. [DOI] [PubMed] [Google Scholar]
  6. Clegg J. B., Naughton M. A., Weatherball D. J. Abnormal human haemoglobins. Separation and characterization of the alpha and beta chains by chromatography, and the determination of two new variants, hb Chesapeak and hb J (Bangkok). J Mol Biol. 1966 Aug;19(1):91–108. doi: 10.1016/s0022-2836(66)80052-9. [DOI] [PubMed] [Google Scholar]
  7. DACIE J. V., GRIMES A. J., MEISLER A., STEINGOLD L., HEMSTED E. H., BEAVEN G. H., WHITE J. C. HEREDITARY HEINZ-BODY ANAEMIA. A REPORT OF STUDIES ON FIVE PATIENTS WITH MILD ANAEMIA. Br J Haematol. 1964 Jul;10:388–402. doi: 10.1111/j.1365-2141.1964.tb00715.x. [DOI] [PubMed] [Google Scholar]
  8. Dacie J. V., Shinton N. K., Gaffney P. J., Jr, Lehmann H. Haemoglobin Hammersmith (beta-42 (CDI) Phe replaced by ser). Nature. 1967 Nov 18;216(5116):663–665. doi: 10.1038/216663a0. [DOI] [PubMed] [Google Scholar]
  9. HUEHNS E. R., SHOOTER E. M. HUMAN HAEMOGLOBINS. J Med Genet. 1965 Mar;2(1):48–90. doi: 10.1136/jmg.2.1.48. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. INGRAM V. M., STRETTON A. O. Human haemoglobin A2. II. The chemistry of some peptides peculiar to haemoglobin A2. Biochim Biophys Acta. 1962 Sep 10;63:20–33. doi: 10.1016/0006-3002(62)90334-7. [DOI] [PubMed] [Google Scholar]
  11. JONES R. T. STRUCTURAL STUDIES OF AMINOETHYLATED HEMOGLOBINS BY AUTOMATIC PEPTIDE CHROMATOGRAPHY. Cold Spring Harb Symp Quant Biol. 1964;29:297–308. doi: 10.1101/sqb.1964.029.01.032. [DOI] [PubMed] [Google Scholar]
  12. Jacob H. S., Brain M. C., Dacie J. V., Carrell R. W., Lehmann H. Abnormal haem binding and globin SH group blockade in unstable haemoglobins. Nature. 1968 Jun 29;218(5148):1214–1217. doi: 10.1038/2181214a0. [DOI] [PubMed] [Google Scholar]
  13. Kleihauer E. F., Reynolds C. A., Dozy A. M., Wilson J. B., Moores R. R., Berenson M. P., Wright C. S., Huisman T. H. Hemoglobin-Bibba or alpha-2-136Pro-beta 2, an unstable alpha chain abnormal hemoglobin. Biochim Biophys Acta. 1968 Jan 22;154(1):220–222. doi: 10.1016/0005-2795(68)90274-2. [DOI] [PubMed] [Google Scholar]
  14. POULIK M. D. Starch gel electrophoresis in a discontinous system of buffers. Nature. 1957 Dec 28;180(4600):1477–1479. doi: 10.1038/1801477a0. [DOI] [PubMed] [Google Scholar]
  15. Perutz M. F., Lehmann H. Molecular pathology of human haemoglobin. Nature. 1968 Aug 31;219(5157):902–909. doi: 10.1038/219902a0. [DOI] [PubMed] [Google Scholar]
  16. Perutz M. F., Muirhead H., Cox J. M., Goaman L. C. Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: the atomic model. Nature. 1968 Jul 13;219(5150):131–139. doi: 10.1038/219131a0. [DOI] [PubMed] [Google Scholar]
  17. Sansone G., Carrell R. W., Lehmann H. Haemoglobin Genova: beta-28 (B10) leucine replaced by proline. Nature. 1967 May 27;214(5091):877–879. doi: 10.1038/214877a0. [DOI] [PubMed] [Google Scholar]
  18. Sick K., Beale D., Irvine D., Lehmann H., Goodall P. T., MacDougall S. Haemoglobin G Copenhagen and haemoglobin J Cambridge. Two new beta-chain variants of haemoglobin A. Biochim Biophys Acta. 1967 Jun 27;140(2):231–242. doi: 10.1016/0005-2795(67)90463-1. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES