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. 1996 Apr;104(4):394–399. doi: 10.1289/ehp.96104394

Pesticide appliers, biocides, and birth defects in rural Minnesota.

V F Garry 1, D Schreinemachers 1, M E Harkins 1, J Griffith 1
PMCID: PMC1469337  PMID: 8732949

Abstract

Earlier studies by our group suggested the possibility that offspring of pesticide appliers might have increased risks of birth anomalies. To evaluate this hypothesis, 935 births to 34,772 state-licensed, private pesticide appliers in Minnesota occurring between 1989 and 1992 were linked to the Minnesota state birth registry containing 210,723 live births in this timeframe. The birth defect rate for all birth anomalies was significantly increased in children born to private appliers. Specific birth defect categories, circulatory/respiratory, urogenital, and musculoskeletal/integumental, showed significant increases. For the general population and for appliers, the birth anomaly rate differed by corp-growing region. Western Minnesota, a major wheat, sugar beet, and potato growing region, showed the highest rate of birth anomalies per/1000 live births: 30.0 for private appliers versus 26.9 for the general population of the same region. The lowest rates, 23.7/1000 for private appliers versus 18.3/1000 for the general population, occurred in noncorp regions. The highest frequency of use of chlorophenoxy herbicides and fungicides also occurred in western Minnesota. Births in the general population of western Minnesota showed a significant increase in birth anomalies in the same three birth anomaly categories as appliers and for central nervous system anomalies. This increase was most pronounced for infants conceived in the spring. The seasonal effect did not occur in other regions. The male/female sex ratio for the four birth anomaly categories of interest in areas of high phenoxy herbicide/fungicide use is 2.8 for appliers versus 1.5 for the general population of the same region (p = 0.05). In minimal use regions, this ratio is 2.1 for appliers versus 1.7 for the general population. The pattern of excess frequency of birth anomalies by pesticide use, season, and alteration of sex ratio suggests exposure-related effects in appliers and the general population of the crop-growing region of western Minnesota.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blakley B. R., Gagnon J. M., Rousseaux C. G. The effect of a commercial 2,4-D formulation on chemical- and viral-induced tumor production in mice. J Appl Toxicol. 1992 Aug;12(4):245–249. doi: 10.1002/jat.2550120406. [DOI] [PubMed] [Google Scholar]
  2. Blakley P. M., Kim J. S., Firneisz G. D. Effects of paternal subacute exposure to Tordon 202c on fetal growth and development in CD-1 mice. Teratology. 1989 Mar;39(3):237–241. doi: 10.1002/tera.1420390305. [DOI] [PubMed] [Google Scholar]
  3. Blakley P. M., Kim J. S., Firneisz G. D. Effects of preconceptional and gestational exposure to Tordon 202c on fetal growth and development in CD-1 mice. Teratology. 1989 Jun;39(6):547–553. doi: 10.1002/tera.1420390605. [DOI] [PubMed] [Google Scholar]
  4. Colborn T., vom Saal F. S., Soto A. M. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect. 1993 Oct;101(5):378–384. doi: 10.1289/ehp.93101378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Garry V. F., Danzl T. J., Tarone R., Griffith J., Cervenka J., Krueger L., Whorton E. B., Jr, Nelson R. L. Chromosome rearrangements in fumigant appliers: possible relationship to non-Hodgkin's lymphoma risk. Cancer Epidemiol Biomarkers Prev. 1992 May-Jun;1(4):287–291. [PubMed] [Google Scholar]
  6. Garry V. F., Griffith J., Danzl T. J., Nelson R. L., Whorton E. B., Krueger L. A., Cervenka J. Human genotoxicity: pesticide applicators and phosphine. Science. 1989 Oct 13;246(4927):251–255. doi: 10.1126/science.2799386. [DOI] [PubMed] [Google Scholar]
  7. Garry V. F., Kelly J. T., Sprafka J. M., Edwards S., Griffith J. Survey of health and use characterization of pesticide appliers in Minnesota. Arch Environ Health. 1994 Sep-Oct;49(5):337–343. doi: 10.1080/00039896.1994.9954984. [DOI] [PubMed] [Google Scholar]
  8. Giwercman A., Carlsen E., Keiding N., Skakkebaek N. E. Evidence for increasing incidence of abnormalities of the human testis: a review. Environ Health Perspect. 1993 Jul;101 (Suppl 2):65–71. doi: 10.1289/ehp.93101s265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hamasaki T., Sato T., Nagase H., Kito H. The mutagenicity of organotin compounds as environmental pollutants. Mutat Res. 1993 Aug;300(3-4):265–271. doi: 10.1016/0165-1218(93)90060-q. [DOI] [PubMed] [Google Scholar]
  10. Imaizumi Y., Yamamura H., Nishikawa M., Matsuoka M., Moriyama I. The prevalence at birth of cogenital malformations at a maternity hospital in Osaka City, 1948-1990. Jinrui Idengaku Zasshi. 1991 Sep;36(3):275–287. doi: 10.1007/BF01910546. [DOI] [PubMed] [Google Scholar]
  11. Jackson M. A., Stack H. F., Waters M. D. The genetic toxicology of putative nongenotoxic carcinogens. Mutat Res. 1993 Mar;296(3):241–277. doi: 10.1016/0165-1110(93)90014-e. [DOI] [PubMed] [Google Scholar]
  12. Kelce W. R., Monosson E., Gamcsik M. P., Laws S. C., Gray L. E., Jr Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicol Appl Pharmacol. 1994 Jun;126(2):276–285. doi: 10.1006/taap.1994.1117. [DOI] [PubMed] [Google Scholar]
  13. Lerda D., Rizzi R. Study of reproductive function in persons occupationally exposed to 2,4-dichlorophenoxyacetic acid (2,4-D). Mutat Res. 1991 Jan;262(1):47–50. doi: 10.1016/0165-7992(91)90105-d. [DOI] [PubMed] [Google Scholar]
  14. Lipkowitz S., Garry V. F., Kirsch I. R. Interlocus V-J recombination measures genomic instability in agriculture workers at risk for lymphoid malignancies. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5301–5305. doi: 10.1073/pnas.89.12.5301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  16. Milham S., Jr Unusual sex ratio of births to carbon setter fathers. Am J Ind Med. 1993 May;23(5):829–831. doi: 10.1002/ajim.4700230516. [DOI] [PubMed] [Google Scholar]
  17. Miyake K., Misawa T., Shigeta S. [The effects of prenatal triphenyltin exposure on learning and development in the rat]. Nihon Eiseigaku Zasshi. 1991 Aug;46(3):769–776. doi: 10.1265/jjh.46.769. [DOI] [PubMed] [Google Scholar]
  18. Noda T., Morita S., Yamano T., Shimizu M., Yamada A. Effects of triphenyltin acetate on pregnancy in rats by oral administration. Toxicol Lett. 1991 Apr;56(1-2):207–212. doi: 10.1016/0378-4274(91)90108-i. [DOI] [PubMed] [Google Scholar]
  19. Pate B. D., Hays R. L. Histological studies of testes in rats treated with certain insect chemosterilants. J Econ Entomol. 1968 Feb;61(1):32–34. doi: 10.1093/jee/61.1.32. [DOI] [PubMed] [Google Scholar]
  20. Pearn J. H. Herbicides and congenital malformations: a review for the paediatrician. Aust Paediatr J. 1985 Nov;21(4):237–242. doi: 10.1111/j.1440-1754.1985.tb00153.x. [DOI] [PubMed] [Google Scholar]
  21. Petrova-Vergieva T., Ivanova-Tchemishanska L. Assessment of the teratogenic activity of dithiocarbamate fungicides. Food Cosmet Toxicol. 1973 Apr;11(2):239–244. doi: 10.1016/s0015-6264(73)80490-0. [DOI] [PubMed] [Google Scholar]
  22. Sharpe R. M., Skakkebaek N. E. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet. 1993 May 29;341(8857):1392–1395. doi: 10.1016/0140-6736(93)90953-e. [DOI] [PubMed] [Google Scholar]
  23. Verma M., Chhatwal J., Singh D. Congenital malformations--a retrospective study of 10,000 cases. Indian J Pediatr. 1991 Mar-Apr;58(2):245–252. doi: 10.1007/BF02751129. [DOI] [PubMed] [Google Scholar]
  24. Yang P., Khoury M. J., Stewart W. F., Beaty T. H., Chee E., Beatty J. C., Diamond E. L., Gordis L. Comparative epidemiology of selected midline congenital abnormalities. Genet Epidemiol. 1994;11(2):141–154. doi: 10.1002/gepi.1370110205. [DOI] [PubMed] [Google Scholar]
  25. Yonemoto J., Shiraishi H., Soma Y. In vitro assessment of teratogenic potential of organotin compounds using rat embryo limb bud cell cultures. Toxicol Lett. 1993 Feb;66(2):183–191. doi: 10.1016/0378-4274(93)90093-d. [DOI] [PubMed] [Google Scholar]

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