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. 1996 Sep;104(9):912–914. doi: 10.1289/ehp.96104912

Mammary gland neoplasia.

D A Neumann 1, T M Crisp 1, S S Olin 1
PMCID: PMC1469452  PMID: 8899366

Abstract

Determining how findings of chemically induced carcinogenic effects in rodents can properly be interpreted for human health poses a continuing challenge to the risk assessment community. One approach begins by comparing and contrasting carcinogenic process in rodents and humans, identifying biologically significant similarities and differences and gaps in scientific knowledge and understanding. Russo and Russo (in this issue) use just such an approach to evaluate the current state of scientific understanding of the comparative mechanisms of mammary tumorigenesis in humans and rodents, particularly the role of reproductive hormones. This commentary describes the basis for this review and suggests some of the implications the report may have for human health risk assessment and for future research.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barrett J. C. Mechanisms for species differences in receptor-mediated carcinogenesis. Mutat Res. 1995 Dec;333(1-2):189–202. doi: 10.1016/0027-5107(95)00145-x. [DOI] [PubMed] [Google Scholar]
  2. Gould M. N. Cellular and molecular aspects of the multistage progression of mammary carcinogenesis in humans and rats. Semin Cancer Biol. 1993 Jun;4(3):161–169. [PubMed] [Google Scholar]
  3. Hatch M., Thomas D. Measurement issues in environmental epidemiology. Environ Health Perspect. 1993 Dec;101 (Suppl 4):49–57. doi: 10.1289/ehp.93101s449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Henderson I. C. Risk factors for breast cancer development. Cancer. 1993 Mar 15;71(6 Suppl):2127–2140. doi: 10.1002/1097-0142(19930315)71:6+<2127::aid-cncr2820711602>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  5. Korenman S. G. Oestrogen window hypothesis of the aetiology of breast cancer. Lancet. 1980 Mar 29;1(8170):700–701. [PubMed] [Google Scholar]
  6. Langston A. A., Malone K. E., Thompson J. D., Daling J. R., Ostrander E. A. BRCA1 mutations in a population-based sample of young women with breast cancer. N Engl J Med. 1996 Jan 18;334(3):137–142. doi: 10.1056/NEJM199601183340301. [DOI] [PubMed] [Google Scholar]
  7. Miller B. A., Feuer E. J., Hankey B. F. The significance of the rising incidence of breast cancer in the United States. Important Adv Oncol. 1994:193–207. [PubMed] [Google Scholar]
  8. Montano M. M., Ekena K., Krueger K. D., Keller A. L., Katzenellenbogen B. S. Human estrogen receptor ligand activity inversion mutants: receptors that interpret antiestrogens as estrogens and estrogens as antiestrogens and discriminate among different antiestrogens. Mol Endocrinol. 1996 Mar;10(3):230–242. doi: 10.1210/mend.10.3.8833652. [DOI] [PubMed] [Google Scholar]
  9. Russo I. H., Russo J. Mammary gland neoplasia in long-term rodent studies. Environ Health Perspect. 1996 Sep;104(9):938–967. doi: 10.1289/ehp.96104938. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sobels F. H. Approaches to assessing genetic risks from exposure to chemicals. Environ Health Perspect. 1993 Oct;101 (Suppl 3):327–332. doi: 10.1289/ehp.93101s3327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Soto A. M., Sonnenschein C. The role of estrogens on the proliferation of human breast tumor cells (MCF-7). J Steroid Biochem. 1985 Jul;23(1):87–94. doi: 10.1016/0022-4731(85)90265-1. [DOI] [PubMed] [Google Scholar]
  12. Wooster R., Neuhausen S. L., Mangion J., Quirk Y., Ford D., Collins N., Nguyen K., Seal S., Tran T., Averill D. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science. 1994 Sep 30;265(5181):2088–2090. doi: 10.1126/science.8091231. [DOI] [PubMed] [Google Scholar]

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