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. 1996 Mar;104(Suppl 1):41–53. doi: 10.1289/ehp.96104s141

Pulmonary reactions to organic dust exposures: development of an animal model.

V Castranova 1, V A Robinson 1, D G Frazer 1
PMCID: PMC1469574  PMID: 8722109

Abstract

Acute inhalation of organic dusts such as cotton, hay, silage, grain, animal confinement, or compost dust can result in illness characterized by fever, pulmonary inflammation, chest tightness, and airway obstruction. These agricultural materials are complex mixtures of plant, bacterial, and fungal products. Elucidation of the time course of disease onset, the mechanisms of disease progression, and the identity of etiologic agents is essential for effective prevention and treatment. Toward this end, animal models for acute organic dust-induced reactions have been developed and characterized. Information concerning the applicability of various animal models to humans and progress toward elucidation of causative agents and mechanisms of action is presented.

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Selected References

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  1. Ainsworth S. K., Neuman R. E. Chemotaxins in cotton mill dust: possible etiologic agent(s) in byssinosis. Am Rev Respir Dis. 1981 Sep;124(3):280–284. doi: 10.1164/arrd.1981.124.3.280. [DOI] [PubMed] [Google Scholar]
  2. Baur X., Borsch-Galetke E., Raulf M., Czuppon A. B., Scheer E. Occupational-type exposure tests and bronchoalveolar lavage analyses in two patients with byssinosis and two asymptomatic cotton workers. Int Arch Occup Environ Health. 1993;65(2):141–146. doi: 10.1007/BF00405734. [DOI] [PubMed] [Google Scholar]
  3. Billiau A., Matthys P., Martens E., Heremans H. Effects of anti-interferon-gamma and anti-interleukin-6 antibodies in disease models in mice: antibodies as carriers of cytokines. J Interferon Res. 1994 Oct;14(5):277–279. doi: 10.1089/jir.1994.14.277. [DOI] [PubMed] [Google Scholar]
  4. Bouhuys A., Barbero A., Schilling R. S., Van de Woestijne K. P. Chronic respiratory disease in hemp workers. Am J Med. 1969 Apr;46(4):526–537. doi: 10.1016/0002-9343(69)90072-2. [DOI] [PubMed] [Google Scholar]
  5. Buck M. G., Wall J. H., Schachter E. N. Airway constrictor response to cotton bract extracts in the absence of endotoxin. Br J Ind Med. 1986 Apr;43(4):220–226. doi: 10.1136/oem.43.4.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Castellan R. M., Olenchock S. A., Hankinson J. L., Millner P. D., Cocke J. B., Bragg C. K., Perkins H. H., Jr, Jacobs R. R. Acute bronchoconstriction induced by cotton dust: dose-related responses to endotoxin and other dust factors. Ann Intern Med. 1984 Aug;101(2):157–163. doi: 10.7326/0003-4819-101-2-157. [DOI] [PubMed] [Google Scholar]
  7. Castellan R. M., Olenchock S. A., Kinsley K. B., Hankinson J. L. Inhaled endotoxin and decreased spirometric values. An exposure-response relation for cotton dust. N Engl J Med. 1987 Sep 3;317(10):605–610. doi: 10.1056/NEJM198709033171005. [DOI] [PubMed] [Google Scholar]
  8. Christiani D. C., Ye T. T., Wegman D. H., Eisen E. A., Dai H. L., Lu P. L. Cotton dust exposure, across-shift drop in FEV1, and five-year change in lung function. Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 1):1250–1255. doi: 10.1164/ajrccm.150.5.7952548. [DOI] [PubMed] [Google Scholar]
  9. Coulombe P. A., Filion P. R., Côté M. G. Histomorphometric study of the pulmonary response of guinea pigs to chronic cotton dust inhalation. Toxicol Appl Pharmacol. 1986 Sep 30;85(3):437–449. doi: 10.1016/0041-008x(86)90351-0. [DOI] [PubMed] [Google Scholar]
  10. Cuss F. M., Dixon C. M., Barnes P. J. Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man. Lancet. 1986 Jul 26;2(8500):189–192. doi: 10.1016/s0140-6736(86)92489-x. [DOI] [PubMed] [Google Scholar]
  11. Czarnetzki B. M., Benveniste J. Effect of 1-O-octadecyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF-acether) on leukocytes I. Analysis of the in vitro migration of human neutrophils. Chem Phys Lipids. 1981 Dec;29(4):317–326. doi: 10.1016/0009-3084(81)90065-7. [DOI] [PubMed] [Google Scholar]
  12. Di Luzio N. R. Lysozyme, glucan-activated macrophages and neoplasia. J Reticuloendothel Soc. 1979 Jul;26(1):67–81. [PubMed] [Google Scholar]
  13. Doherty G. M., Lange J. R., Langstein H. N., Alexander H. R., Buresh C. M., Norton J. A. Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha. J Immunol. 1992 Sep 1;149(5):1666–1670. [PubMed] [Google Scholar]
  14. Donham K. J. Health effects from work in swine confinement buildings. Am J Ind Med. 1990;17(1):17–25. doi: 10.1002/ajim.4700170105. [DOI] [PubMed] [Google Scholar]
  15. Ellakkani M. A., Alarie Y. C., Weyel D. A., Karol M. H. Concentration-dependent respiratory response of guinea pigs to a single exposure of cotton dust. Toxicol Appl Pharmacol. 1985 Sep 15;80(2):357–366. doi: 10.1016/0041-008x(85)90093-6. [DOI] [PubMed] [Google Scholar]
  16. Ellakkani M. A., Alarie Y. C., Weyel D. A., Mazumdar S., Karol M. H. Pulmonary reactions to inhaled cotton dust: an animal model for byssinosis. Toxicol Appl Pharmacol. 1984 Jun 30;74(2):267–284. doi: 10.1016/0041-008x(84)90152-2. [DOI] [PubMed] [Google Scholar]
  17. Ellakkani M. A., Alarie Y., Weyel D., Karol M. H. Chronic pulmonary effects in guinea pigs from prolonged inhalation of cotton dust. Toxicol Appl Pharmacol. 1987 May;88(3):354–369. doi: 10.1016/0041-008x(87)90211-0. [DOI] [PubMed] [Google Scholar]
  18. Enarson D. A., Chan-Yeung M. Characterization of health effects of wood dust exposures. Am J Ind Med. 1990;17(1):33–38. doi: 10.1002/ajim.4700170107. [DOI] [PubMed] [Google Scholar]
  19. Fedan J. S., Robinson V. A., Hay D. W., Weber K. C. An overview of species differences in the effects of a water extract of cotton bract on isolated airway smooth muscle, and effects of E. coli lipopolysaccharide. Environ Health Perspect. 1986 Apr;66:159–165. doi: 10.1289/ehp.8666159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Fedan J. S., Warner T. E., Yuan L. X., Robinson V. a., Frazer D. G. Nitric oxide synthase inhibitor and lipopolysaccharide effects on reactivity of guinea pig airways. J Pharmacol Exp Ther. 1995 Mar;272(3):1141–1150. [PubMed] [Google Scholar]
  21. Fishwick D., Fletcher A. M., Pickering C. A., Niven R. M., Faragher E. B. Respiratory symptoms and dust exposure in Lancashire cotton and man-made fiber mill operatives. Am J Respir Crit Care Med. 1994 Aug;150(2):441–447. doi: 10.1164/ajrccm.150.2.8049827. [DOI] [PubMed] [Google Scholar]
  22. Frazer D. G., Jones W. G., Petsonk E. L., Kullman G. J., Barger M. W., Afshari A., Jones T., Castranova V. Organic dust exposure from compost handling: response of an animal model. Am J Ind Med. 1993 Oct;24(4):375–385. doi: 10.1002/ajim.4700240404. [DOI] [PubMed] [Google Scholar]
  23. Glindmeyer H. W., Lefante J. J., Jones R. N., Rando R. J., Weill H. Cotton dust and across-shift change in FEV1 as predictors of annual change in FEV1. Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):584–590. doi: 10.1164/ajrccm.149.3.8118622. [DOI] [PubMed] [Google Scholar]
  24. Gordon T., Balmes J., Fine J., Sheppard D. Airway oedema and obstruction in guinea pigs exposed to inhaled endotoxin. Br J Ind Med. 1991 Sep;48(9):629–635. doi: 10.1136/oem.48.9.629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Gordon T. The role of inflammatory mediators in airway edema and obstruction produced in guinea pigs exposed to inhaled endotoxin or cotton dusts. Am J Ind Med. 1990;17(1):107–108. doi: 10.1002/ajim.4700170135. [DOI] [PubMed] [Google Scholar]
  26. Haglind P., Lundholm M., Rylander R. Prevalence of byssinosis in Swedish cotton mills. Br J Ind Med. 1981 May;38(2):138–143. doi: 10.1136/oem.38.2.138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Hurst T. S., Dosman J. A. Characterization of health effects of grain dust exposures. Am J Ind Med. 1990;17(1):27–32. doi: 10.1002/ajim.4700170106. [DOI] [PubMed] [Google Scholar]
  28. Jacobs R. R., Boehlecke B., van Hage-Hamsten M., Rylander R. Bronchial reactivity, atopy, and airway response to cotton dust. Am Rev Respir Dis. 1993 Jul;148(1):19–24. doi: 10.1164/ajrccm/148.1.19. [DOI] [PubMed] [Google Scholar]
  29. Jacobs R. R. Sampling environments containing organic dust. Am J Ind Med. 1994 Jan;25(1):3–11. doi: 10.1002/ajim.4700250105. [DOI] [PubMed] [Google Scholar]
  30. Kennedy S. M., Christiani D. C., Eisen E. A., Wegman D. H., Greaves I. A., Olenchock S. A., Ye T. T., Lu P. L. Cotton dust and endotoxin exposure-response relationships in cotton textile workers. Am Rev Respir Dis. 1987 Jan;135(1):194–200. doi: 10.1164/arrd.1987.135.1.194. [DOI] [PubMed] [Google Scholar]
  31. Larsson K. A., Eklund A. G., Hansson L. O., Isaksson B. M., Malmberg P. O. Swine dust causes intense airways inflammation in healthy subjects. Am J Respir Crit Care Med. 1994 Oct;150(4):973–977. doi: 10.1164/ajrccm.150.4.7921472. [DOI] [PubMed] [Google Scholar]
  32. Lecours R., Laviolette M., Cormier Y. Bronchoalveolar lavage in pulmonary mycotoxicosis (organic dust toxic syndrome). Thorax. 1986 Dec;41(12):924–926. doi: 10.1136/thx.41.12.924. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Malmberg P. Health effects of organic dust exposure in dairy farmers. Am J Ind Med. 1990;17(1):7–15. doi: 10.1002/ajim.4700170104. [DOI] [PubMed] [Google Scholar]
  34. Malmberg P., Rask-Andersen A., Höglund S., Kolmodin-Hedman B., Read Guernsey J. Incidence of organic dust toxic syndrome and allergic alveolitis in Swedish farmers. Int Arch Allergy Appl Immunol. 1988;87(1):47–54. doi: 10.1159/000234647. [DOI] [PubMed] [Google Scholar]
  35. Mattsby I., Rylander R. Clinical and immunological findings in workers exposed to sewage dust. J Occup Med. 1978 Oct;20(10):690–692. [PubMed] [Google Scholar]
  36. McKERROW C. B., McDERMOTT M., GILSON J. C., SCHILLING R. S. Respiratory function during the day in cotton workers: a study in byssinosis. Br J Ind Med. 1958 Apr;15(2):75–83. doi: 10.1136/oem.15.2.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Merchant J. A., Halprin G. M., Hudson A. R., Kilburn K. H., McKenzie W. N., Hurst D. J., Bermazohn P. Responses to cotton dust. Arch Environ Health. 1975 May;30(5):222–229. doi: 10.1080/00039896.1975.10666685. [DOI] [PubMed] [Google Scholar]
  38. Merchant J. A., Kilburn K. H., O'Fallon W. M., Hamilton J. D., Lumsden J. C. Byssinosis and chronic bronchitis among cotton textile workers. Ann Intern Med. 1972 Mar;76(3):423–433. doi: 10.7326/0003-4819-76-3-423. [DOI] [PubMed] [Google Scholar]
  39. Moira C. Y., Enarson D. A., Kennedy S. M. The impact of grain dust on respiratory health. Am Rev Respir Dis. 1992 Feb;145(2 Pt 1):476–487. doi: 10.1164/ajrccm/145.2_Pt_1.476. [DOI] [PubMed] [Google Scholar]
  40. Morrison D. C., Ulevitch R. J. The effects of bacterial endotoxins on host mediation systems. A review. Am J Pathol. 1978 Nov;93(2):526–618. [PMC free article] [PubMed] [Google Scholar]
  41. Olenchock S. A., Lenhart S. W., Mull J. C. Occupational exposure to airborne endotoxins during poultry processing. J Toxicol Environ Health. 1982 Feb;9(2):339–349. doi: 10.1080/15287398209530166. [DOI] [PubMed] [Google Scholar]
  42. Olenchock S. A., May J. J., Pratt D. S., Morey P. R. Occupational exposures to airborne endotoxins in agriculture. Prog Clin Biol Res. 1987;231:475–487. [PubMed] [Google Scholar]
  43. Organic dusts and lung diseases. Proceedings of an international workshop. Skokloster, Sweden, October 24-27, 1988. Am J Ind Med. 1990;17(1):1–148. [PubMed] [Google Scholar]
  44. Petsonk E. L., Olenchock S. A., Castellan R. M., Banks D. E., Mull J. C., Hankinson J. L., Bragg K. C., Perkins H. H., Cocke J. B. Human ventilatory response to washed and unwashed cottons from different growing areas. Br J Ind Med. 1986 Mar;43(3):182–187. doi: 10.1136/oem.43.3.182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. ROACH S. A., SCHILLING R. S. A clinical and environmental study of byssinosis in the Lancashire cotton industry. Br J Ind Med. 1960 Jan;17:1–9. doi: 10.1136/oem.17.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Rask-Andersen A., Malmberg P. Organic dust toxic syndrome in Swedish farmers: symptoms, clinical findings, and exposure in 98 cases. Am J Ind Med. 1990;17(1):116–117. doi: 10.1002/ajim.4700170139. [DOI] [PubMed] [Google Scholar]
  47. Reynolds H. Y. Hypersensitivity pneumonitis: correlation of cellular and immunologic changes with clinical phases of disease. Lung. 1988;166(4):189–208. doi: 10.1007/BF02714049. [DOI] [PubMed] [Google Scholar]
  48. Ryan L. K., Karol M. H. Acute respiratory response of guinea pigs to lipopolysaccharide, lipid A, and monophosphoryl lipid A from Salmonella minnesota. Am Rev Respir Dis. 1989 Nov;140(5):1429–1435. doi: 10.1164/ajrccm/140.5.1429. [DOI] [PubMed] [Google Scholar]
  49. Ryan L. K., Karol M. H. Release of tumor necrosis factor in guinea pigs upon acute inhalation of cotton dust. Am J Respir Cell Mol Biol. 1991 Jul;5(1):93–98. doi: 10.1165/ajrcmb/5.1.93. [DOI] [PubMed] [Google Scholar]
  50. Rylander R., Beijer L. Inhalation of endotoxin stimulates alveolar macrophage production of platelet-activating factor. Am Rev Respir Dis. 1987 Jan;135(1):83–86. doi: 10.1164/arrd.1987.135.1.83. [DOI] [PubMed] [Google Scholar]
  51. Rylander R. Diseases associated with exposure to plant dusts: focus on cotton dust. Tuber Lung Dis. 1992 Feb;73(1):21–26. doi: 10.1016/0962-8479(92)90075-U. [DOI] [PubMed] [Google Scholar]
  52. Rylander R., Schilling R. S., Pickering C. A., Rooke G. B., Dempsey A. N., Jacobs R. R. Effects after acute and chronic exposure to cotton dust: the Manchester criteria. Br J Ind Med. 1987 Sep;44(9):577–579. doi: 10.1136/oem.44.9.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Rylander R., Snella M. C. Endotoxins and the lung: cellular reactions and risk for disease. Prog Allergy. 1983;33:332–344. [PubMed] [Google Scholar]
  54. SCHILLING R. S., HUGHES J. P., DINGWALL-FORDYCE I., GILSON J. C. An epidemiological study of byssinosis among Lancashire cotton workers. Br J Ind Med. 1955 Jul;12(3):217–227. doi: 10.1136/oem.12.3.217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Shvedova A. A., Kramarik J. A., Keohavong P., Chumakov K. M., Karol M. H. Use of anti-TNF-alpha antiserum to investigate toxic alveolitis arising from cotton dust exposure. Exp Lung Res. 1994 Jul-Aug;20(4):297–315. doi: 10.3109/01902149409064389. [DOI] [PubMed] [Google Scholar]
  56. Smith J. A., Frazer D. G., Fedan J. S. Alteration in the modulatory role of respiratory epithelium after exposure of guinea pigs to respirable cotton dust. J Pharmacol Exp Ther. 1993 Feb;264(2):683–688. [PubMed] [Google Scholar]
  57. Thorne P. S., Yeske C. P., Karol M. H. Monitoring guinea pig core temperature by telemetry during inhalation exposures. Fundam Appl Toxicol. 1987 Oct;9(3):398–408. doi: 10.1016/0272-0590(87)90022-4. [DOI] [PubMed] [Google Scholar]
  58. Van Dyke K., Castranova V., Van Dyke C. J., Ma J., Michaux K., Mollison K. W., Carter G. W. Granulocyte response to oxidized FMLP. Evidence for partial inactivation of FMLP. Inflammation. 1984 Mar;8(1):87–99. doi: 10.1007/BF00918356. [DOI] [PubMed] [Google Scholar]
  59. Van der Zwan J. C., Orie N. G., Kauffman H. F., Wiers P. W., de Vries K. Bronchial obstructive reactions after inhalation with endotoxin and precipitinogens of Haemophilus influenzae in patients with chronic non-specific lung disease. Clin Allergy. 1982 Nov;12(6):547–559. doi: 10.1111/j.1365-2222.1982.tb02553.x. [DOI] [PubMed] [Google Scholar]
  60. Von Essen S. G., Robbins R. A., Thompson A. B., Ertl R. F., Linder J., Rennard S. Mechanisms of neutrophil recruitment to the lung by grain dust exposure. Am Rev Respir Dis. 1988 Oct;138(4):921–927. doi: 10.1164/ajrccm/138.4.921. [DOI] [PubMed] [Google Scholar]
  61. Weber S., Kullman G., Petsonk E., Jones W. G., Olenchock S., Sorenson W., Parker J., Marcelo-Baciu R., Frazer D., Castranova V. Organic dust exposures from compost handling: case presentation and respiratory exposure assessment. Am J Ind Med. 1993 Oct;24(4):365–374. doi: 10.1002/ajim.4700240403. [DOI] [PubMed] [Google Scholar]
  62. Weyel D. A., Ellakkani M., Alarie Y., Karol M. An aerosol generator for the resuspension of cotton dust. Toxicol Appl Pharmacol. 1984 Dec;76(3):544–547. doi: 10.1016/0041-008x(84)90359-4. [DOI] [PubMed] [Google Scholar]
  63. de Rochemonteix-Galve B., Marchat-Amoruso B., Dayer J. M., Rylander R. Tumor necrosis factor and interleukin-1 activities in free lung cells after single and repeated inhalation of bacterial endotoxin. Infect Immun. 1991 Oct;59(10):3646–3650. doi: 10.1128/iai.59.10.3646-3650.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. doPico G. A. Health effects of organic dusts in the farm environment. Report on diseases. Am J Ind Med. 1986;10(3):261–265. doi: 10.1002/ajim.4700100310. [DOI] [PubMed] [Google Scholar]
  65. von Essen S. G., Thompson A. B., Robbins R. A., Jones K. K., Dobry C. A., Rennard S. I. Lower respiratory tract inflammation in grain farmers. Am J Ind Med. 1990;17(1):75–76. doi: 10.1002/ajim.4700170119. [DOI] [PubMed] [Google Scholar]

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